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Literature summary for 2.1.1.233 extracted from

  • DeGrande, S.; Little, S.; Nixon, D.; Wright, P.; Snyder, J.; Dun, W.; Murphy, N.; Kilic, A.; Higgins, R.; Binkley, P.; Boyden, P.; Carnes, C.; Anderson, M.; Hund, T.; Mohler, P.
    Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart (2013), J. Biol. Chem., 288, 1032-1046.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.233

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 Homo sapiens
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart left ventricular tissue Homo sapiens
-
myocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309
-
 Homo sapiens S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
LCMT-1
-
 Homo sapiens
leucine carboxymethyltransferase 1/phosphatase methylesterase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction decreased phosphatase 2A protein catalytic subunit methylation is linked with decreased LCMT-1 expression causing human heart failure, overview Homo sapiens
metabolism past global read-outs of cellular PP2A activity more appropriately represent the collective activity of numerous individual PP2A holoenzymes, each displaying a specific subcellular localization (dictated by select PP2A regulatory subunits) as well as local specific post-translational catalytic subunit methylation and phosphorylation events that regulate local and rapid holoenzyme assembly/disassembly via leucine carboxymethyltransferase 1/phosphatase methylesterase 1 (LCMT-1/PME-1), PP2A regulation system involving nine different PP2A regulatory subunits (PPP2R2A, PPP2R2B, PPP2R3A, PPP2R4, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, and PPP2R5E) in the heart. LCMT-1 and PME-1 show cell-type and disease-linked expressional regulation, overview Homo sapiens