Literature summary for 2.1.1.233 extracted from

Sontag, J.; Nunbhakdi-Craig, V.; Mitterhuber, M.; Ogris, E.; Sontag, E.
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells (2010), J. Neurochem., 115, 1455-1465.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Neuro-2a cell	-	Mus musculus	-
neuroblastoma cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine	-	Mus musculus	S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester	-	?

Synonyms

Synonyms	Comment	Organism
LCMT1	-	Mus musculus
leucine carboxy methyltransferase-1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	regulation of protein phosphatase 2A methylation by leucine carboxy methyltransferase-1 (LCMT1) plays a critical role in differentiation of neuroblastoma cells. Enhanced expression of LCMT1 in cultured N2a neuroblastoma cells induces changes in F-actin organization. Expression of LCMT1 promotes the formation of elongated neurite-like processes	Mus musculus

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Release 2023.1 (January 2023)