Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | - |
Mus musculus | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | - |
Homo sapiens | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCMT-1 | - |
Mus musculus |
LCMT-1 | - |
Homo sapiens |
leucine carboxy methyltransferase-1 | - |
Mus musculus |
leucine carboxy methyltransferase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | homozygous gene trap knock-out of leucine carboxyl methyltransferase-1 in mice results in embryonic lethality | Mus musculus |
malfunction | leucine carboxyl methyltransferase-1 (LCMT-1) knockdown reduces the formation of protein phosphatase 2A heterotrimers containing the Balpha regulatory subunit and, in a subset of the cells, induces apoptosis, characterized by caspase activation, nuclear condensation/fragmentation, and membrane blebbing. LCMT-1 knockdown cells are more sensitive to the spindle-targeting drug nocodazole | Homo sapiens |
physiological function | leucine carboxyl methyltransferase-1 (LCMT-1) is essential for embryonic development in mice. LCMT-1 is important for spindle checkpoint | Mus musculus |
physiological function | leucine carboxyl methyltransferase-1 (LCMT-1) is necessary for normal progression through mitosis and cell survival. LCMT-1 is important for spindle checkpoint | Homo sapiens |