Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine | the enzyme catalyzes the methylation of the phosphatase 2A protein C subunit carboxyl-terminal leucine | Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatase 2A protein methyltransferase | - |
Saccharomyces cerevisiae |
Ppm1p | major phosphatase 2A protein methyltransferase in Saccharomyces cerevisiae | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of phosphatase 2A protein methyltransferase PPM1 greatly reduces Cdc55p, Tpd3p, and Rts1p binding and leads to nocodazole sensitivity | Saccharomyces cerevisiae |
physiological function | carboxymethylation of the PP2A catalytic subunit by phosphatase 2A protein methyltransferase PPM1 in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p | Saccharomyces cerevisiae |