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Literature summary for 2.1.1.231 extracted from

  • Kim, M.; Kim, B.; Ahn, J.
    Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli (2013), Appl. Microbiol. Biotechnol., 97, 7195-7204.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, recombinant expression in Escherichia coli, functional coexpression of plant enzymes, e.g. 4-coumaroyl-CoA ligase and chalcone synthase, of different origins catalyzing steps in flavonoid biosynthesis pathways for production of naringenin from p-coumaric acid and synthesis of ponciretin and sakuranetin from naringenin in engineered and transformed Escherichia coli strain BL21(DE3) Glycine max

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + naringenin Glycine max i.e. 4',5,7-trihyroxyflavanone, the enzyme transfers a methyl group to 4'-hydroxyl group of naringenin S-adenosyl-L-homocysteine + ponciretin i.e. 4'-methoxy-5,7-dihydroxyflavanone ?

Organism

Organism UniProt Comment Textmining
Glycine max C6TAY1 cv. Paldal
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + naringenin i.e. 4',5,7-trihyroxyflavanone, the enzyme transfers a methyl group to 4'-hydroxyl group of naringenin Glycine max S-adenosyl-L-homocysteine + ponciretin i.e. 4'-methoxy-5,7-dihydroxyflavanone ?
S-adenosyl-L-methionine + naringenin i.e. 4',5,7-trihyroxyflavanone, reaction of SOMT-2 Glycine max S-adenosyl-L-homocysteine + ponciretin i.e. 4'-methoxy-5,7-dihydroxyflavanone ?

Synonyms

Synonyms Comment Organism
SOMT2
-
Glycine max
soybean O-methyltransferase
-
Glycine max

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Glycine max

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the last step in the biosynthesis of the bioactive flavonoid ponciretin, biosynthetic pathways starting with glucose, overview Glycine max