Literature summary for 2.1.1.230 extracted from

Thompson, J.; Schmidt, F.; Cundliffe, E.
Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton (1982), J. Biol. Chem., 257, 7915-7917.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA	Streptomyces azureus	the methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton	S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces azureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA	-	Streptomyces azureus	S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA	-	?
S-adenosyl-L-methionine + adenosine1067 in 23S rRNA	the methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton	Streptomyces azureus	S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA	-	?

General Information

General Information	Comment	Organism
physiological function	the methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton	Streptomyces azureus

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Release 2023.1 (January 2023)