Application | Comment | Organism |
---|---|---|
medicine | transurethral injection of ALKBH8 small interfering RNA (siRNA) offers promise as a new therapeutic strategy for bladder cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96BT7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
urothelial carcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ALKBH8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of ALKBH8 through small interfering RNA transfection reduced reactive oxygen species (ROS) production via down-regulation of NAD(P)H oxidase-1 (NOX-1) and induced apoptosis through subsequent activation of c-jun NH2-terminal kinase (JNK) and p38. Silencing of ALKBH8 significantly suppresses invasion, angiogenesis, and growth of bladder cancers in vivo | Homo sapiens |
physiological function | ALKBH8 is an upstream target of NOX-1 and is involved in intracellular ROS generation. ALKBH8/NOX-1 signals function mainly in the acquisition of the aggressive human urothelial carcinoma phenotype | Homo sapiens |