Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | - |
Escherichia coli | |
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | - |
Methanocaldococcus jannaschii | |
6-Chloropurine | - |
Escherichia coli | |
6-Chloropurine | - |
Methanocaldococcus jannaschii | |
adenosine | - |
Escherichia coli | |
adenosine | - |
Methanocaldococcus jannaschii | |
AdoButyn | an S-adenosyl-L-methionine analogue | Escherichia coli | |
AdoButyn | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
AdoPropen | an S-adenosyl-L-methionine analogue | Escherichia coli | |
AdoPropen | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
Inosine | - |
Escherichia coli | |
Inosine | - |
Methanocaldococcus jannaschii | |
methionine | - |
Escherichia coli | |
methionine | - |
Methanocaldococcus jannaschii | |
methylthioadenosine | - |
Escherichia coli | |
methylthioadenosine | - |
Methanocaldococcus jannaschii | |
additional information | fragments of S-adenosyl-L-methionine, adenosine and methionine, are selectively inhibitory of TrmD, while they are poor inhibitors for Trm5 from Methanocaldococcus jannaschii | Escherichia coli | |
additional information | fragments of S-adenosyl-L-methionine, adenosine and methionine, are poor inhibitors of Trm5, while they are selectve inhibitors for TrmD from Escherichia coli | Methanocaldococcus jannaschii | |
S-adenosyl-L-homocysteine | an S-adenosyl-L-methionine analogue | Escherichia coli | |
S-adenosyl-L-homocysteine | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
S-methyl-L-cysteine | - |
Escherichia coli | |
S-methyl-L-cysteine | - |
Methanocaldococcus jannaschii | |
sinefungin | an S-adenosyl-L-methionine analogue | Escherichia coli | |
sinefungin | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview | Escherichia coli | |
additional information | - |
additional information | S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview | Methanocaldococcus jannaschii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine37 in tRNA | Escherichia coli | - |
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? | |
S-adenosyl-L-methionine + guanine37 in tRNA | Methanocaldococcus jannaschii | - |
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Methanocaldococcus jannaschii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine37 in tRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? | |
S-adenosyl-L-methionine + guanine37 in tRNA | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TRM5 | - |
Methanocaldococcus jannaschii |
TrmD | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
55 | - |
assay at | Methanocaldococcus jannaschii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | Trm5 binding structure, detailed overview | Methanocaldococcus jannaschii | |
S-adenosyl-L-methionine | TrmD binding structure, detailed overview | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics of S-adenosyl-L-methionine analogues, overview | Escherichia coli | |
additional information | - |
additional information | inhibition kinetics of S-adenosyl-L-methionine analogues, overview | Methanocaldococcus jannaschii | |
0.00033 | - |
sinefungin | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.00049 | - |
S-adenosyl-L-homocysteine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.00062 | - |
sinefungin | pH not specified in the publication, 37°C | Escherichia coli | |
0.0012 | - |
methylthioadenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.00143 | - |
AdoPropen | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.0031 | - |
AdoButyn | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.0042 | - |
S-adenosyl-L-homocysteine | pH not specified in the publication, 37°C | Escherichia coli | |
0.0079 | - |
AdoButyn | pH not specified in the publication, 37°C | Escherichia coli | |
0.01 | - |
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | pH not specified in the publication, 37°C | Escherichia coli | |
0.014 | - |
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.0259 | - |
AdoPropen | pH not specified in the publication, 37°C | Escherichia coli | |
0.03 | - |
methylthioadenosine | pH not specified in the publication, 37°C | Escherichia coli | |
0.0347 | - |
adenosine | pH not specified in the publication, 37°C | Escherichia coli | |
0.0642 | - |
adenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.405 | - |
6-Chloropurine | pH not specified in the publication, 37°C | Escherichia coli | |
0.461 | - |
6-Chloropurine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
0.488 | - |
Inosine | pH not specified in the publication, 37°C | Escherichia coli | |
6.7 | - |
methionine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
13.4 | - |
Inosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
18.2 | - |
methionine | pH not specified in the publication, 37°C | Escherichia coli | |
33 | - |
S-methyl-L-cysteine | pH not specified in the publication, 37°C | Escherichia coli | |
44 | - |
S-methyl-L-cysteine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii |