Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.227 extracted from

  • Monshupanee, T.
    Increased bacterial hemolytic activity is conferred by expression of TlyA methyltransferase but not by its 2'-O-methylation of the ribosome (2013), Curr. Microbiol., 67, 61-68.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene tlyA, recombinant expression of C-terminally His-tagged enzyme in Escherichia coli Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycobacterium tuberculosis the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 ?
-
?
additional information Mycobacterium tuberculosis H37Rv the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 ?
-
?
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA Mycobacterium tuberculosis
-
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJ63 gene tlyA
-
Mycobacterium tuberculosis H37Rv P9WJ63 gene tlyA
-

Purification (Commentary)

Purification (Comment) Organism
recombinant C-terminally His-tagged enzyme from Escherichia coli Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 Mycobacterium tuberculosis ?
-
?
additional information the recombinant enzyme poorly modifies the nucleotide C1409 in vitro in all Escherichia coli ribosomal substrates evaluated: 16S rRNA, 30S ribosomal subunits, and 70S ribosomes Mycobacterium tuberculosis ?
-
?
additional information the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 Mycobacterium tuberculosis H37Rv ?
-
?
additional information the recombinant enzyme poorly modifies the nucleotide C1409 in vitro in all Escherichia coli ribosomal substrates evaluated: 16S rRNA, 30S ribosomal subunits, and 70S ribosomes Mycobacterium tuberculosis H37Rv ?
-
?
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
-
?

Synonyms

Synonyms Comment Organism
2'-O-methyltransferase
-
Mycobacterium tuberculosis
TlyA
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function bacterial 2'-O-methyltransferase TlyA methylates either both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA. Both ribosomal methylations increase bacterial susceptibility to ribosome targeting antibiotics capreomycin and viomycin. The enzyme also function as a hemolysin, but increased bacterial hemolytic function is not likely a consequence of TlyA-mediated methylations of the ribosome Mycobacterium tuberculosis