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Literature summary for 2.1.1.211 extracted from

  • Kotelawala, L.; Grayhack, E.J.; Phizicky, E.M.
    Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species (2008), RNA, 14, 158-169.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + uridine44 in tRNASer Saccharomyces cerevisiae 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA) S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q02648
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-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + uridine44 in tRNASer
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Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
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?
S-adenosyl-L-methionine + uridine44 in tRNASer 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA) Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 2'-O-methyluridine44 in tRNASer
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?

Synonyms

Synonyms Comment Organism
TRM44
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction trm44-DELTA strain lacks 2'-O-methyltransferase activity and has undetectable levels of Um44 in its tRNASer. Although trm44-DELTA mutants have no detectable growth defect, TRM44 is required for survival at 33°C in a tan1-DELTA mutant strain, which lacks ac4C12 in tRNASer and tRNALeu Saccharomyces cerevisiae