BRENDA - Enzyme Database show
show all sequences of 2.1.1.202

Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae

Burgess, A.; David, R.; Searle, I.; BMC Plant Biol. 15, 199 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
trm4a and trm4b, phylogenetic analysis
Arabidopsis thaliana
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Arabidopsis thaliana
5634
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Arabidopsis thaliana
identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview. The enzyme does not methylate cytosines at structural positions C47, C48, C49 and C72. Identification of modified cytosines in Arabidopsis thaliana nuclear transcribed tRNAs which are dependent on RMTases TRDMT1 and TRM4B. No cytosine 5-methylation sites are detected in Arabidopsis chloroplast or mitochondrial tRNAs, which is in contrast to animal mitochondrial tRNAs
?
-
-
-
additional information
Brassica rapa
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Triticum turgidum subsp. durum
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Ginkgo biloba
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Nannochloropsis oculata
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Caulerpa taxifolia
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
-
two putative TRM4/NSUN2 paralogues, TRM4A and TRM4B
-
Brassica rapa
-
-
-
Caulerpa taxifolia
-
-
-
Ginkgo biloba
-
-
-
Nannochloropsis oculata
-
-
-
Triticum turgidum subsp. durum
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
additional information
tRNAHis m5C levels are unusually responsive to yeast growth conditions
Nannochloropsis oculata
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview. The enzyme does not methylate cytosines at structural positions C47, C48, C49 and C72. Identification of modified cytosines in Arabidopsis thaliana nuclear transcribed tRNAs which are dependent on RMTases TRDMT1 and TRM4B. No cytosine 5-methylation sites are detected in Arabidopsis chloroplast or mitochondrial tRNAs, which is in contrast to animal mitochondrial tRNAs
735864
Arabidopsis thaliana
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Brassica rapa
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Triticum turgidum subsp. durum
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Ginkgo biloba
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Nannochloropsis oculata
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Caulerpa taxifolia
?
-
-
-
-
additional information
motif I is essential for methyltransferase activity and is required for S-adenosyl-L-methionine binding and catalysis. Enzyme variant Trm4a is lacking motif I in contrast to enzyme variant Trm4b
735864
Arabidopsis thaliana
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Arabidopsis thaliana
S-adenosyl-L-methionine
-
Brassica rapa
S-adenosyl-L-methionine
-
Caulerpa taxifolia
S-adenosyl-L-methionine
-
Ginkgo biloba
S-adenosyl-L-methionine
-
Nannochloropsis oculata
S-adenosyl-L-methionine
-
Triticum turgidum subsp. durum
Cloned(Commentary) (protein specific)
Commentary
Organism
trm4a and trm4b, phylogenetic analysis
Arabidopsis thaliana
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Arabidopsis thaliana
S-adenosyl-L-methionine
-
Brassica rapa
S-adenosyl-L-methionine
-
Caulerpa taxifolia
S-adenosyl-L-methionine
-
Ginkgo biloba
S-adenosyl-L-methionine
-
Nannochloropsis oculata
S-adenosyl-L-methionine
-
Triticum turgidum subsp. durum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Arabidopsis thaliana
5634
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Arabidopsis thaliana
identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview. The enzyme does not methylate cytosines at structural positions C47, C48, C49 and C72. Identification of modified cytosines in Arabidopsis thaliana nuclear transcribed tRNAs which are dependent on RMTases TRDMT1 and TRM4B. No cytosine 5-methylation sites are detected in Arabidopsis chloroplast or mitochondrial tRNAs, which is in contrast to animal mitochondrial tRNAs
?
-
-
-
additional information
Brassica rapa
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Triticum turgidum subsp. durum
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Ginkgo biloba
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Nannochloropsis oculata
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
additional information
Caulerpa taxifolia
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
additional information
tRNAHis m5C levels are unusually responsive to yeast growth conditions
Nannochloropsis oculata
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview. The enzyme does not methylate cytosines at structural positions C47, C48, C49 and C72. Identification of modified cytosines in Arabidopsis thaliana nuclear transcribed tRNAs which are dependent on RMTases TRDMT1 and TRM4B. No cytosine 5-methylation sites are detected in Arabidopsis chloroplast or mitochondrial tRNAs, which is in contrast to animal mitochondrial tRNAs
735864
Arabidopsis thaliana
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Brassica rapa
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Triticum turgidum subsp. durum
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Ginkgo biloba
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Nannochloropsis oculata
?
-
-
-
-
additional information
identification of single-nucleotide resolution of m5C sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species, overview
735864
Caulerpa taxifolia
?
-
-
-
-
additional information
motif I is essential for methyltransferase activity and is required for S-adenosyl-L-methionine binding and catalysis. Enzyme variant Trm4a is lacking motif I in contrast to enzyme variant Trm4b
735864
Arabidopsis thaliana
?
-
-
-
-
General Information
General Information
Commentary
Organism
evolution
Identification of m5C sites in nuclear, chloroplast and mitochondrial tRNAs. 39 cytosine 5-methylation sites are identified at 5 structural positions and are located in tRNA secondary structure at positions C38, C48, C49, C50 and C72, pattern of methylation in individual tRNA isodecoders, overview. Identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species. Both the nucleotide position and percent methylation of tRNAs and rRNAs cytosine 5-methylation sites are conserved across all species analysed, overview
Arabidopsis thaliana
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed, overview
Brassica rapa
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed
Caulerpa taxifolia
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed, overview
Ginkgo biloba
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites were conserved across all species analysed
Nannochloropsis oculata
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites were conserved across all species analysed
Triticum turgidum subsp. durum
malfunction
in trm4a defective mutants, the cytosine 5-methylation profile is the same as wild-type, showing that TRM4A is not required for methylation of any of the detected tRNAs. In contrast for trm4b-1 and trm4b-2 mutants, a total of 18 sites have no detectable methylation and 7 sites have reduced methylation when compared to wild-type, the sites are corresponding to structural positions C48, C49, and C50. trdmt1/trm4b double mutants are hypersensitive to the antibiotic hygromycin B
Arabidopsis thaliana
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine is an important modification that regulates RNA metabolism. Nuclear tRNA methylation requires two evolutionarily conserved methyltransferases, TRDMT1 and TRM4B
Arabidopsis thaliana
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Brassica rapa
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Caulerpa taxifolia
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Ginkgo biloba
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Nannochloropsis oculata
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Triticum turgidum subsp. durum
General Information (protein specific)
General Information
Commentary
Organism
evolution
Identification of m5C sites in nuclear, chloroplast and mitochondrial tRNAs. 39 cytosine 5-methylation sites are identified at 5 structural positions and are located in tRNA secondary structure at positions C38, C48, C49, C50 and C72, pattern of methylation in individual tRNA isodecoders, overview. Identification of single-nucleotide resolution of cytosine 5-methylation sites in non-coding ribosomal RNAs and transfer RNAs of all three subcellular transcriptomes across six diverse species. Both the nucleotide position and percent methylation of tRNAs and rRNAs cytosine 5-methylation sites are conserved across all species analysed, overview
Arabidopsis thaliana
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed, overview
Brassica rapa
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed
Caulerpa taxifolia
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites are conserved across all species analysed, overview
Ginkgo biloba
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites were conserved across all species analysed
Nannochloropsis oculata
evolution
both the nucleotide position and percent methylation of tRNAs and rRNAs m5C sites were conserved across all species analysed
Triticum turgidum subsp. durum
malfunction
in trm4a defective mutants, the cytosine 5-methylation profile is the same as wild-type, showing that TRM4A is not required for methylation of any of the detected tRNAs. In contrast for trm4b-1 and trm4b-2 mutants, a total of 18 sites have no detectable methylation and 7 sites have reduced methylation when compared to wild-type, the sites are corresponding to structural positions C48, C49, and C50. trdmt1/trm4b double mutants are hypersensitive to the antibiotic hygromycin B
Arabidopsis thaliana
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine is an important modification that regulates RNA metabolism. Nuclear tRNA methylation requires two evolutionarily conserved methyltransferases, TRDMT1 and TRM4B
Arabidopsis thaliana
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Brassica rapa
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Caulerpa taxifolia
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Ginkgo biloba
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Nannochloropsis oculata
physiological function
post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification that regulates RNA metabolism
Triticum turgidum subsp. durum
Other publictions for EC 2.1.1.202
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735864
Burgess
Conservation of tRNA and rRNA ...
Arabidopsis thaliana, Brassica rapa, Caulerpa taxifolia, Ginkgo biloba, Nannochloropsis oculata, Triticum turgidum subsp. durum
BMC Plant Biol.
15
199
2015
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1
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1
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6
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19
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1
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7
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6
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1
6
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1
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6
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1
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7
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13
13
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735680
Moon
Trm4 and Nsun2 RNA:m5C methylt ...
Saccharomyces cerevisiae
Biochemistry
53
7132-7144
2014
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1
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2
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2
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1
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1
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1
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1
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2
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1
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2
2
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735907
Hussain
NSun2-mediated cytosine-5 meth ...
Homo sapiens
Cell Rep.
4
255-261
2013
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2
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10
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1
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1
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11
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1
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1
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2
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10
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1
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11
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1
2
2
1
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736856
Khoddami
Identification of direct targe ...
Homo sapiens
Nat. Biotechnol.
31
458-464
2013
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1
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2
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1
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8
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1
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4
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1
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9
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1
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1
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1
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8
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1
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9
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2
2
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737227
Preston
TRNAHis 5-methylcytidine level ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
RNA
19
243-256
2013
1
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11
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58
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13
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11
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13
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1
3
3
1
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719968
Awai
Substrate tRNA recognition mec ...
Methanocaldococcus jannaschii
J. Biol. Chem.
286
35236-35246
2011
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1
1
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2
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1
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1
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1
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3
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1
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1
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710546
Walbott
Cysteine of sequence motif VI ...
Saccharomyces cerevisiae
RNA
13
967-973
2007
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1
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3
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1
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672512
Redman
Assembly of protein-RNA comple ...
Saccharomyces cerevisiae
Biomacromolecules
7
3321-3326
2006
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2
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2
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710135
Brzezicha
Identification of human tRNA:m ...
Saccharomyces cerevisiae
Nucleic Acids Res.
34
6034-6043
2006
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1
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3
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3
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1
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1
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639472
King
RNA methyltransferases utilize ...
Saccharomyces cerevisiae
Biochemistry
41
11218-11225
2002
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2
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3
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1
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639471
Motorin
Multisite-specific tRNA:m5C-me ...
Saccharomyces cerevisiae
RNA
5
1105-1118
1999
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1
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3
4
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4
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1
4
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8
1
1
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1
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1
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3
4
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1
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8
1
1
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1
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2
2
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710134
Jiang
Pleiotropic effects of intron ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae Pp1001
Nucleic Acids Res.
25
2694-2701
1997
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2
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4
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1
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4
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1
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1
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709946
Strobel
Effect of intron mutations on ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
6
2663-2673
1986
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