Literature summary for 2.1.1.20 extracted from

Yen, C.H.; Hung, J.H.; Ueng, Y.F.; Liu, S.P.; Chen, S.Y.; Liu, H.H.; Chou, T.Y.; Tsai, T.F.; Darbha, R.; Hsieh, L.L.; Chen, Y.M.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect (2009), Toxicol. Appl. Pharmacol., 235, 296-304.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus liver and kidney	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	GNMT is translocated into nuclei after aflatoxin B1 treatment	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + glycine	-	Homo sapiens	S-adenosyl-L-homocysteine + N-methylglycine	-	?

Synonyms

Synonyms	Comment	Organism
GNMT	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	GNMT is a tumor suppressor for hepatocellular carcinoma cells and it exerts protective effects in hepatocytes via direct interaction with aflatoxin B1, resulting in reduced aflatoxin B1-DNA adducts formation and cell death	Homo sapiens

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Release 2023.1 (January 2023)