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Literature summary for 2.1.1.20 extracted from
- Glycine N-methyltransferase and regulation of S-adenosylmethionine levels (2009), J. Biol. Chem., 284, 22507-22511.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucagon | GNMT activity is induced by glucagon | Mus musculus |  |
| glucagon | GNMT activity is induced by glucagon | Homo sapiens | |
| glucagon | GNMT activity is induced by glucagon | Sus scrofa | |
| glucagon | GNMT activity is induced by glucagon | Oryctolagus cuniculus | |
| glucagon | GNMT activity is induced by glucagon | Danio rerio | |
| glucagon | GNMT activity is induced by glucagon | Rattus norvegicus | |
| Vitamin A | GNMT activity is induced by vitamin A | Mus musculus | |
| Vitamin A | GNMT activity is induced by vitamin A | Homo sapiens | |
| Vitamin A | GNMT activity is induced by vitamin A | Sus scrofa | |
| Vitamin A | GNMT activity is induced by vitamin A | Oryctolagus cuniculus | |
| Vitamin A | GNMT activity is induced by vitamin A | Danio rerio | |
| Vitamin A | GNMT activity is induced by vitamin A | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-Methyltetrahydrofolate pentaglutamate | - |
Danio rerio | |
| 5-Methyltetrahydrofolate pentaglutamate | - |
Homo sapiens | |
| 5-Methyltetrahydrofolate pentaglutamate | - |
Mus musculus | |
| 5-Methyltetrahydrofolate pentaglutamate | - |
Oryctolagus cuniculus | |
| 5-Methyltetrahydrofolate pentaglutamate | - |
Rattus norvegicus | |
| 5-Methyltetrahydrofolate pentaglutamate | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Danio rerio | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| nucleus | presence in liver nuclei | Mus musculus | 5634 | - |
| nucleus | presence in liver nuclei | Homo sapiens | 5634 | - |
| nucleus | presence in liver nuclei | Sus scrofa | 5634 | - |
| nucleus | presence in liver nuclei | Oryctolagus cuniculus | 5634 | - |
| nucleus | presence in liver nuclei | Danio rerio | 5634 | - |
| nucleus | presence in liver nuclei | Rattus norvegicus | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32500 | - |
4 * 32500 | Mus musculus |
| 32500 | - |
4 * 32500 | Homo sapiens |
| 32500 | - |
4 * 32500 | Sus scrofa |
| 32500 | - |
4 * 32500 | Oryctolagus cuniculus |
| 32500 | - |
4 * 32500 | Danio rerio |
| 32500 | - |
4 * 32500 | Rattus norvegicus |
| 130000 | - |
- |
Mus musculus |
| 130000 | - |
- |
Homo sapiens |
| 130000 | - |
- |
Sus scrofa |
| 130000 | - |
- |
Oryctolagus cuniculus |
| 130000 | - |
- |
Danio rerio |
| 130000 | - |
- |
Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | P13255 | - |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellar Purkinje cell | - |
Mus musculus | - |
| cerebellar Purkinje cell | - |
Homo sapiens | - |
| cerebellar Purkinje cell | - |
Oryctolagus cuniculus | - |
| cerebellar Purkinje cell | - |
Rattus norvegicus | - |
| cerebral cortical neuron | - |
Mus musculus | - |
| cerebral cortical neuron | - |
Homo sapiens | - |
| cerebral cortical neuron | - |
Oryctolagus cuniculus | - |
| cerebral cortical neuron | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Mus musculus | - |
| intestinal mucosa | - |
Homo sapiens | - |
| intestinal mucosa | - |
Oryctolagus cuniculus | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Danio rerio | - |
| liver | - |
Rattus norvegicus | - |
| pancreas | - |
Mus musculus | - |
| pancreas | - |
Homo sapiens | - |
| pancreas | - |
Sus scrofa | - |
| pancreas | - |
Oryctolagus cuniculus | - |
| pancreas | - |
Rattus norvegicus | - |
| prostate gland | - |
Mus musculus | - |
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Sus scrofa | - |
| prostate gland | - |
Oryctolagus cuniculus | - |
| prostate gland | - |
Rattus norvegicus | - |
| renal proximal tubule | - |
Mus musculus | - |
| renal proximal tubule | - |
Homo sapiens | - |
| renal proximal tubule | - |
Oryctolagus cuniculus | - |
| renal proximal tubule | - |
Rattus norvegicus | - |
| submandibular gland | - |
Mus musculus | - |
| submandibular gland | - |
Homo sapiens | - |
| submandibular gland | - |
Oryctolagus cuniculus | - |
| submandibular gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + glycine | - |
Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
| S-adenosyl-L-methionine + glycine | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
| S-adenosyl-L-methionine + glycine | - |
Sus scrofa | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
| S-adenosyl-L-methionine + glycine | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
| S-adenosyl-L-methionine + glycine | - |
Danio rerio | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
| S-adenosyl-L-methionine + glycine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | 4 * 32500 | Mus musculus |
| homotetramer | 4 * 32500 | Homo sapiens |
| homotetramer | 4 * 32500 | Sus scrofa |
| homotetramer | 4 * 32500 | Oryctolagus cuniculus |
| homotetramer | 4 * 32500 | Danio rerio |
| homotetramer | 4 * 32500 | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycine methyltransferase | - |
Mus musculus |
| glycine methyltransferase | - |
Homo sapiens |
| glycine methyltransferase | - |
Sus scrofa |
| glycine methyltransferase | - |
Oryctolagus cuniculus |
| glycine methyltransferase | - |
Danio rerio |
| glycine methyltransferase | - |
Rattus norvegicus |
| GNMT | - |
Mus musculus |
| GNMT | - |
Homo sapiens |
| GNMT | - |
Sus scrofa |
| GNMT | - |
Oryctolagus cuniculus |
| GNMT | - |
Danio rerio |
| GNMT | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Mus musculus |
| 9 | - |
- |
Homo sapiens |
| 9 | - |
- |
Sus scrofa |
| 9 | - |
- |
Oryctolagus cuniculus |
| 9 | - |
- |
Danio rerio |
| 9 | - |
- |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0013 | - |
native enzyme | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate | |
| 0.59 | - |
recombinant enzyme | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
| Homo sapiens | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
| Sus scrofa | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
| Oryctolagus cuniculus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
| Danio rerio | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
| Rattus norvegicus | GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Gnmt knockout mice develop fatty livers when they have increased S-adenosyl-L-methionine | Mus musculus |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Mus musculus |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Homo sapiens |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Sus scrofa |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Oryctolagus cuniculus |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Danio rerio |
| metabolism | GNMT is involved in both hepatic methyl group and one-carbon metabolism | Rattus norvegicus |
| physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Mus musculus |
| physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Homo sapiens |
| physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Sus scrofa |
| physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Oryctolagus cuniculus |
| physiological function | GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels | Rattus norvegicus |
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