Application | Comment | Organism |
---|---|---|
medicine | GNMT is a tumor suppressor gene for liver cancer, and is associated with gender disparity in liver cancer susceptibility | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + glycine | - |
Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycine methyltransferase | - |
Mus musculus |
GNMT | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Gnmt knockout mice develop hepatocellular carcinoma, hemangioma, dysplastic nodules, fatty nodules and lung metastasis, DNA methyltransferase activity is decreased in 11 weeks old Gnmt knockout mice, the MAPK pathway is activated in female Gnmt knockout mice | Mus musculus |