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Literature summary for 2.1.1.20 extracted from

  • Liao, Y.J.; Liu, S.P.; Lee, C.M.; Yen, C.H.; Chuang, P.C.; Chen, C.Y.; Tsai, T.F.; Huang, S.F.; Lee, Y.H.; Chen, Y.M.
    Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility (2009), Int. J. Cancer, 124, 816-826.
    View publication on PubMed

Application

Application Comment Organism
medicine GNMT is a tumor suppressor gene for liver cancer, and is associated with gender disparity in liver cancer susceptibility Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
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Mus musculus
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liver
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + glycine
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Mus musculus S-adenosyl-L-homocysteine + N-methylglycine
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?

Synonyms

Synonyms Comment Organism
glycine methyltransferase
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Mus musculus
GNMT
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Mus musculus

General Information

General Information Comment Organism
malfunction Gnmt knockout mice develop hepatocellular carcinoma, hemangioma, dysplastic nodules, fatty nodules and lung metastasis, DNA methyltransferase activity is decreased in 11 weeks old Gnmt knockout mice, the MAPK pathway is activated in female Gnmt knockout mice Mus musculus