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Literature summary for 2.1.1.20 extracted from

  • Huang, Y.C.; Chen, M.; Shyr, Y.M.; Su, C.H.; Chen, C.K.; Li, A.F.; Ho, D.M.; Chen, Y.M.
    Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma (2008), J. Gastroenterol. Hepatol., 23, 1384-1389.
    View publication on PubMed
Search for more literature for 2.1.1.20

Application

Application Comment Organism
diagnostics enzyme level suitable as prognostic marker for human cholangiocarcinoma and hepatocellular carcinoma Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm concentrated in the paranuclear region near the bile duct lumen Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens major folate binding protein ?
-
 ?
S-adenosyl-L-methionine + glycine Homo sapiens key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 cholangiocarcinoma patients
-

Source Tissue

Source Tissue Comment Organism Textmining
bile duct high expression in normal tissue, reduced expression in tumorous tissue, some tumor samples show no enzyme expression Homo sapiens
-
cholangiocyte
-
 Homo sapiens
-
liver high expression in normal tissue, only 4% of hepatocellular carcinoma show GNMT expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major folate binding protein Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Synonyms

Synonyms Comment Organism
GNMT
-
 Homo sapiens