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Literature summary for 2.1.1.20 extracted from
- Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats (2006), Am. J. Physiol. Endocrinol. Metab., 291, E1235-E1242.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | diabetes increases the activity and abundance of GNMT, lack of dietary folate results in the highest activity of GNMT in diabetic rats without the abundance of the protein being altered | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | folate-containing diets attenuate GNMT activity in diabetic rats but are without effect on abundance | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | activity of GNMT is increased about 2fold in diabetic liver | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + glycine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + sarcosine | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GNMT | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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