Literature summary for 2.1.1.2 extracted from

Schneider, J.E.; Stork, L.A.; Bell, J.T.; Hove, M.T.; Isbrandt, D.; Clarke, K.; Watkins, H.; Lygate, C.A.; Neubauer, S.
Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study (2008), J. Cardiovasc. Magn. Reson., 10, 1-9.

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Application

Application	Comment	Organism
medicine	since creatine plays an important role in the buffering and transfer of high-energy phosphate bonds in the heart, it is hypothesized that lack of creatine would be detrimental for resting cardiac performance during ageing	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + guanidinoacetate	Mus musculus	-	S-adenosyl-L-homocysteine + creatine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanidinoacetate	-	Mus musculus	S-adenosyl-L-homocysteine + creatine	-	?

Synonyms

Synonyms	Comment	Organism
GAMT	-	Mus musculus
guanidinoacetate N-methyltransferase	-	Mus musculus

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Release 2023.1 (January 2023)