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Literature summary for 2.1.1.188 extracted from
- The tylosin-resistance methyltransferase RlmAII (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748 (2004), J. Mol. Biol., 337, 1073-1077.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine748 in 23S rRNA | Streptomyces fradiae | the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
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Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces fradiae | Q9S1M6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine748 in 23S rRNA | the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome | Streptomyces fradiae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? | |
| S-adenosyl-L-methionine + guanine748 in 23S rRNA | the methylation site of RlmAII is identified by liquid chromatography/electrospray ionization mass spectrometry as the N-1 position of 23S rRNA nucleotide G748 | Streptomyces fradiae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RlmA(II) | - |
Streptomyces fradiae |
| RlmAII | - |
Streptomyces fradiae |
| TlrB | - |
Streptomyces fradiae |
| tylosin-resistance methyltransferase RlmA(II) | - |
Streptomyces fradiae |
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Release 2023.1 (January 2023)
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