Literature summary for 2.1.1.182 extracted from

Formenoy, L.J.; Cunningham, P.R.; Nurse, K.; Pleij, C.W.A.; Ofengand, J.
Methylation of the conserved A1518-A1519 in Escherichia coli 16S ribosomal RNA by the ksgA methyltransferase is influenced by methylations around the similarly conserved U1512-G1523 base pair in the 3' terminal hairpin (1994), Biochimie, 76, 1123-1128.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA	dimethylation of AI518 and A1519 in the hairpin loop of 16S rRNA. Site-specific mutagenesis of 16S rRNA of Escherichia coli ribosomes is used to make five mutations around the highly conserved UI512-GI523 base pair in the 3'-terminal hairpin. G1523 and C1524 in the stem are important determinants for the dimethylation of A1518 and AI519 in the loop	Escherichia coli	4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA	-	?

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Release 2023.1 (January 2023)