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Literature summary for 2.1.1.180 extracted from

  • Dunkle, J.A.; Vinal, K.; Desai, P.M.; Zelinskaya, N.; Savic, M.; West, D.M.; Conn, G.L.; Dunham, C.M.
    Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA (2014), Proc. Natl. Acad. Sci. USA, 111, 6275-6280.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.180

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with the 30S ribosome subunit and sinefungin Escherichia coli

Protein Variants

Protein Variants Comment Organism
E146A functionally compromised mutant Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine1408 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA Escherichia coli ARS3
-
 S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli A8C927
-
-
Escherichia coli ARS3 A8C927
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
-
 Escherichia coli ARS3 S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?
sinefungin + adenine1408 in 16S rRNA
-
 Escherichia coli ?
-
 ?
sinefungin + adenine1408 in 16S rRNA
-
 Escherichia coli ARS3 ?
-
 ?

Synonyms

Synonyms Comment Organism
NpmA
-
 Escherichia coli
plasmid-mediated 16S rRNA methyltransferase A
-
 Escherichia coli