Literature summary for 2.1.1.179 extracted from

Beauclerk, A.A.; Cundliffe, E.
Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides (1987), J. Mol. Biol., 193, 661-671.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA	Micromonospora echinospora	the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine	S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Micromonospora echinospora	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA	-	Micromonospora echinospora	S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA	-	?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA	the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine	Micromonospora echinospora	S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA	-	?

General Information

General Information	Comment	Organism
physiological function	the enzyme gives resistance to kanamycin plus gentamicin by converting guanine1405 to 7-methylguanine	Micromonospora echinospora

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Release 2023.1 (January 2023)