Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.179 extracted from

  • Kojic, M.; Topisirovic, L.; Vasiljevic, B.
    Translational autoregulation of the sgm gene from Micromonospora zionensis (1996), J. Bacteriol., 178, 5493-5498.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.179

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Micromonospora zionensis the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Micromonospora zionensis Q7M0R2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
sgm
-
 Micromonospora zionensis
sisomicin-gentamicin resistance methylase
-
 Micromonospora zionensis

General Information

General Information Comment Organism
physiological function encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides. The expression of the sgm gene is regulated by the translational autorepression Micromonospora zionensis