Application | Comment | Organism |
---|---|---|
analysis | development of A system that transports phosphatidylethanolamine to the mitochondria where it is methylated to phosphatidylcholine and phosphatidylcholine is transported back to other organelles and supports the growth of the mutants defective in phosphatidylcholine synthesis | Acetobacter aceti |
Organism | UniProt | Comment | Textmining |
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Acetobacter aceti | - |
- |
- |
Acetobacter aceti NBRC 3283 | - |
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- |
General Information | Comment | Organism |
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physiological function | recombinant expression of phosphatidylethanolamine methyltransferase from Acetobacter aceti, fused with a mitochondrial targeting signal from yeast, in Saccharomyces cerevisiae. The expression suppresses the choline auxotrophy of a double deletion mutant of endogenous phosphatidylethanolamine methyltransferases PEM1 and PEM2 and enables synthesis of phosphatidylcholine in the absence of choline. This growth suppression is observed even if the Kennedy pathway is inactivated by the repression of PCT1 encoding CTP:phosphocholine cytidylyltransferase | Acetobacter aceti |