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Literature summary for 2.1.1.17 extracted from

  • Li, Z.; Agellon, L.B.; Vance, D.E.
    A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis (2007), Biochim. Biophys. Acta, 1771, 893-900.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient female Pemt-/- mice maintain hepatic PC/total choline levels during the first day of choline deprivation and escaped liver damage whereas male Pemt-/- mice do not, plasma phosphocholine levels in high-density lipoproteins are higher in male Pemt-/- mice than those in females before choline deprivation, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus a striking gender-specific conservation of choline in female mice does not occur in male mice ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 and 129/J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary culture Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a striking gender-specific conservation of choline in female mice does not occur in male mice Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
PEMT
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Mus musculus