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Literature summary for 2.1.1.17 extracted from

  • Zhu, X.; Zeisel, S.H.
    Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice (2005), Brain Res. Mol. Brain Res., 134, 239-255.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine. ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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fetuses (embryonic day 17) Pemt -/- and wild type mice and 12-week-old Pemt -/- and wild type mice. For E17 fetal brain microarrays, 11 separate oligoarrays (comparing wild type and Pemt -/-) including 4 dye-flip experiments are perfomed and indentified differntially expressed genes: 107 significant genes with increased expression and 379 significant genes with decreased expression. For adult brain microarrays, 8 separate oligoarrays (comparing wild type and Pemt -/-) including 4 dye-flip experiments are perfomed and identified differentially expressed genes: 381 significant genes with increased expression and 1037 significant genes with decreased expression.
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine. Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
PEMT
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Mus musculus