BRENDA - Enzyme Database show
show all sequences of 2.1.1.152

The biosynthesis of adenosylcobalamin (vitamin B12)

Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.; Nat. Prod. Rep. 19, 390-412 (2002)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + precorrin-5 + H2O
Pseudomonas denitrificans (nomen rejiciendum)
the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
Pseudomonas denitrificans (nomen rejiciendum)
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas denitrificans (nomen rejiciendum)
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + precorrin-5 + H2O
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
?
S-adenosyl-L-methionine + precorrin-5 + H2O
the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
644278
Pseudomonas denitrificans (nomen rejiciendum)
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + precorrin-5 + H2O
Pseudomonas denitrificans (nomen rejiciendum)
the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
Pseudomonas denitrificans (nomen rejiciendum)
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + precorrin-5 + H2O
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
?
S-adenosyl-L-methionine + precorrin-5 + H2O
the enzyme is involved in cobalamin biosynthesis, aerobic or late cobalt insertion pathway
644278
Pseudomonas denitrificans (nomen rejiciendum)
S-adenosyl-L-homocysteine + precorrin-6A + acetate
-
644278
Pseudomonas denitrificans (nomen rejiciendum)
?
Other publictions for EC 2.1.1.152
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
644278
Warren
The biosynthesis of adenosylco ...
Pseudomonas denitrificans (nomen rejiciendum)
Nat. Prod. Rep.
19
390-412
2002
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3209
Roessner
Overexpression in Escherichia ...
Pseudomonas denitrificans (nomen rejiciendum)
Protein Expr. Purif.
6
155-163
1995
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15270
Debussche
Biosynthesis of the corrin mac ...
Pseudomonas denitrificans (nomen rejiciendum)
J. Bacteriol.
175
7430-7440
1993
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