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Literature summary for 2.1.1.148 extracted from

  • Escartin, F.; Skouloubris, S.; Liebl, U.; Myllykallio, H.
    Flavin-dependent thymidylate synthase X limits chromosomal DNA replication (2008), Proc. Natl. Acad. Sci. USA, 105, 9948-9952.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.148

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
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Paramecium bursaria Chlorella virus 1
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Expression

Organism Comment Expression
Paramecium bursaria Chlorella virus 1 replacement of Escherichia coli thyA gene, EC 2.1.1.45, by thyX and expression under the native thyA promoter. In thymidine-deprived solid and liquid growth media, the mutant strain grows poorly compared with the wild-type strain and is impaired in DNA replication additional information

General Information

General Information Comment Organism
physiological function DNA replication speed in bacteria and archaea that contain the low-activity ThyX enzyme is up to 10fold decreased compared with species that contain the catalytically more efficient ThyA, EC 2.1.1.45. Both ThyX and ThyA participate in frequent reciprocal gene replacement events. The bacterial metabolism continues to modulate the size and composition of prokaryotic genomes. The increased kinetic efficiency of thymidylate synthesis may have contributed to extending the prokaryotic evolutionary potential Helicobacter pylori
physiological function DNA replication speed in bacteria and archaea that contain the low-activity ThyX enzyme is up to 10fold decreased compared with species that contain the catalytically more efficient ThyA, EC 2.1.1.45. Both ThyX and ThyA participate in frequent reciprocal gene replacement events. The bacterial metabolism continues to modulate the size and composition of prokaryotic genomes. The increased kinetic efficiency of thymidylate synthesis may have contributed to extending the prokaryotic evolutionary potential Paramecium bursaria Chlorella virus 1