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Literature summary for 2.1.1.148 extracted from

  • Esra Onen, F.; Boum, Y.; Jacquement, C.; Spanedda, M.V.; Jaber, N.; Scherman, D.; Myllykallio, H.; Herscovici, J.
    Design, synthesis and evaluation of potent thymidylate synthase X inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 3628-3631.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(heptanoyl[[(4R)-2-phenyl-3-(phenylcarbonyl)-1,3-thiazolidin-4-yl]methyl] amino)acetic acid
-
Paramecium bursaria Chlorella virus 1
ethyl (4R)-2-phenyl-3-([(1-(3-2,2,2-trifluoroacetamido)propyl)-1H-1,2,3-triazol-4-yl]carbonyl)-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
ethyl (4R)-2-phenyl-3-[[1-(2-thiophen-3-ylethyl)-1H-1,2,3-triazol-4-yl]carbonyl]-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
ethyl (4R)-3-([1-[2-(4-fluorophenyl)ethyl]-1H-1,2,3-triazol-4-yl]carbonyl)-2-phenyl-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
ethyl (4R)-3-[[1-(7-hydroxyheptyl)-1H-1,2,3-triazol-4-yl]carbonyl]-2-phenyl-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2 Paramecium bursaria Chlorella virus 1
-
dTMP + tetrahydrofolate + FAD
-
?

Organism

Organism UniProt Comment Textmining
Paramecium bursaria Chlorella virus 1 O41156
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
Paramecium bursaria Chlorella virus 1 dTMP + tetrahydrofolate + FAD
-
?

Synonyms

Synonyms Comment Organism
thymidylate synthase X
-
Paramecium bursaria Chlorella virus 1
ThyX
-
Paramecium bursaria Chlorella virus 1

Cofactor

Cofactor Comment Organism Structure
FAD FAD/NAPDH couple Paramecium bursaria Chlorella virus 1
NADPH FAD/NAPDH couple Paramecium bursaria Chlorella virus 1

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000057
-
ethyl (4R)-2-phenyl-3-([(1-(3-2,2,2-trifluoroacetamido)propyl)-1H-1,2,3-triazol-4-yl]carbonyl)-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
0.00013
-
(heptanoyl[[(4R)-2-phenyl-3-(phenylcarbonyl)-1,3-thiazolidin-4-yl]methyl] amino)acetic acid
-
Paramecium bursaria Chlorella virus 1
0.001
-
ethyl (4R)-2-phenyl-3-[[1-(2-thiophen-3-ylethyl)-1H-1,2,3-triazol-4-yl]carbonyl]-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
0.002
-
ethyl (4R)-3-([1-[2-(4-fluorophenyl)ethyl]-1H-1,2,3-triazol-4-yl]carbonyl)-2-phenyl-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1
0.0035
-
ethyl (4R)-3-[[1-(7-hydroxyheptyl)-1H-1,2,3-triazol-4-yl]carbonyl]-2-phenyl-1,3-thiazolidine-4-carboxylate
-
Paramecium bursaria Chlorella virus 1