Literature summary for 2.1.1.142 extracted from

Holmberg, N.; Harker, M.; Wallace, A.D.; Clayton, J.C.; Gibbard, C.L.; Safford, R.
Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols (2003), Plant J., 36, 12-20.

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Cloned(Commentary)

Cloned (Comment)	Organism
coexpression of the catalytic domain of Hevea brasiliensis 3-hydroxy-3-methylglutaryl CoA reductase and Nicotiana tabacum C24-sterol methyltransferase type 1 in tobacco, under control of both constitutive and seed-specific promoters, resulting in increased accumulation of total sterol in seed tissue by 2.5fold and 2.1fold, respectively	Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol	Nicotiana tabacum	3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 work in concert to control carbon flux into end-product sterols. Sterol composition can be controlled by the temporal activity of the promoters driving transgene expression	S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol	-	?

Organism

Organism	UniProt	Comment	Textmining
Nicotiana tabacum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol	3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 work in concert to control carbon flux into end-product sterols. Sterol composition can be controlled by the temporal activity of the promoters driving transgene expression	Nicotiana tabacum	S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol	-	?

Synonyms

Synonyms	Comment	Organism
C24-sterol methyltransferase type 1	-	Nicotiana tabacum
SMT1	-	Nicotiana tabacum

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Release 2023.1 (January 2023)