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Literature summary for 2.1.1.137 extracted from
- New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT) (2010), Biochimie, 92, 1397-1406.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + arsenite | maximal conversion of arsenite to monomethylarsonate occurs at about 0.1 mM arsenite. Higher substrate concentrations inhibit monomethylarsonate yields. The production of dimethylarsinic acid increases as arsenite concentration increases from 0.0005 to 0.0083 mM, and then quickly decreases to zero | Homo sapiens | S-adenosyl-L-homocysteine + monomethylarsonate + dimethylarsinic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arsenic (+3) methyltransferase | - |
Homo sapiens |
| AS3MT | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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