BRENDA - Enzyme Database show
show all sequences of 2.1.1.137

New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT)

Song, X.; Geng, Z.; Li, X.; Hu, X.; Bian, N.; Zhang, X.; Wang, Z.; Biochimie 92, 1397-1406 (2010)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
glutathione
GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + arsenite
maximal conversion of arsenite to monomethylarsenate occurs at about 0.1 mM arsenite. Higher substrate concentrations inhibit monomethylarsenate yields. The production of dimethylarsenate increases as arsenite concentration increases from 0.0005 to 0.0083 mM, and then quickly decreases to zero
719007
Homo sapiens
S-adenosyl-L-homocysteine + monomethylarsenate + dimethylarsenate
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7
10
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
glutathione
GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + arsenite
maximal conversion of arsenite to monomethylarsenate occurs at about 0.1 mM arsenite. Higher substrate concentrations inhibit monomethylarsenate yields. The production of dimethylarsenate increases as arsenite concentration increases from 0.0005 to 0.0083 mM, and then quickly decreases to zero
719007
Homo sapiens
S-adenosyl-L-homocysteine + monomethylarsenate + dimethylarsenate
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7
10
-
Homo sapiens
Other publictions for EC 2.1.1.137
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733175
Zhang
Arsenic methylation and volati ...
Pseudomonas alcaligenes, Pseudomonas alcaligenes NBRC 14159
Appl. Environ. Microbiol.
81
2852-2860
2015
-
-
1
-
-
-
-
-
-
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1
4
-
5
-
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1
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-
-
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4
1
1
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-
1
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1
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1
4
-
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-
1
-
-
-
-
4
1
1
-
-
-
1
-
-
-
1
2
2
1
-
-
733887
Wang
Identification and catalytic r ...
Clostridium sp., Clostridium sp. BXM
FEMS Microbiol. Lett.
362(4)
1-8
2015
-
-
1
-
-
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1
4
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5
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4
1
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1
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1
4
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4
1
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733203
Ye
Identification and characteriz ...
Tetrahymena pyriformis
Aquat. Toxicol.
149
50-57
2014
-
-
1
-
-
-
-
-
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2
3
-
5
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1
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1
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1
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3
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1
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3
1
-
1
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-
1
-
-
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-
-
-
733425
Li
Mutational analysis of residue ...
Homo sapiens
Biochimie
107 Pt B
396-405
2014
-
-
-
-
16
-
-
10
-
-
-
1
-
2
-
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1
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16
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10
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1
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-
1
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
733740
Wang
Identification and characteriz ...
Methanosarcina acetivorans
Environ. Sci. Technol.
48
12706-12713
2014
4
-
1
-
-
-
-
-
-
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2
-
5
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2
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1
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2
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735126
Wang
The functions of crucial cyste ...
Homo sapiens
PLoS ONE
9
e110924
2014
-
-
1
-
1
-
-
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-
1
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2
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1
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1
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1
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1
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1
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1
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1
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-
735309
Tokumoto
Arsenic (+3 oxidation state) m ...
Homo sapiens
Toxicol. Rep.
1
589-595
2014
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
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1
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1
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3
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1
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2
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1
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1
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3
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-
733865
Li
Functional evaluation of Asp76 ...
Homo sapiens
FEBS Lett.
587
2232-2240
2013
-
-
1
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8
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2
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2
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2
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2
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8
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2
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2
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-
718946
Marapakala
Identification of catalytic re ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
944-951
2012
1
-
1
-
4
-
-
-
-
-
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5
-
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1
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2
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1
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1
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1
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4
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1
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2
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1
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-
721074
Hamdi
Identification of an S-adenosy ...
Danio rerio
Toxicol. Appl. Pharmacol.
262
185-193
2012
-
-
1
-
2
-
2
-
-
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1
-
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6
-
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1
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10
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1
1
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1
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2
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2
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1
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1
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10
-
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1
1
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721075
Ding
Methylation of arsenic by reco ...
Homo sapiens
Toxicol. Appl. Pharmacol.
264
121-130
2012
1
-
1
-
1
-
1
7
-
-
-
-
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2
-
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1
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2
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7
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1
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2
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1
1
-
-
-
733333
Ajees
Structure of an As(III) S-aden ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
5476-5485
2012
-
-
1
1
-
-
-
-
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1
4
-
4
-
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1
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4
1
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1
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1
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1
4
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1
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4
1
-
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-
733451
Sumi
Role of arsenic (+3 oxidation ...
Homo sapiens
Biol. Pharm. Bull.
35
1870-1875
2012
-
-
-
-
1
-
-
-
-
-
1
2
-
1
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5
-
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2
1
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1
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1
2
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5
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2
1
-
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-
-
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-
733950
Huang
-
Crystallization and preliminar ...
Rhodopseudomonas palustris
He Jishu Nuclear Techniques
35
326-330
2012
-
-
1
1
-
-
-
-
-
-
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2
-
1
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1
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2
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1
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1
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2
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1
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2
-
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-
734199
Wang
Rapid equilibrium kinetic anal ...
Homo sapiens
J. Biol. Chem.
287
38790-38799
2012
-
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1
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-
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2
-
2
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1
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2
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1
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2
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1
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2
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718712
Fujihara
Genetic variants associated wi ...
Homo sapiens
Arch. Toxicol.
85
119-125
2011
-
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-
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1
-
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2
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1
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1
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1
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718748
Sumi
Alternative splicing variants ...
Homo sapiens
Biochem. Biophys. Res. Commun.
415
48-53
2011
-
-
1
-
1
-
-
-
-
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2
-
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3
-
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1
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5
-
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1
1
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1
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1
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2
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1
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5
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1
1
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1
1
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-
719012
Song
Functional and structural eval ...
Homo sapiens
Biochimie
93
369-375
2011
-
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1
-
5
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10
-
-
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3
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1
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1
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1
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5
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10
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1
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1
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719007
Song
New insights into the mechanis ...
Homo sapiens
Biochimie
92
1397-1406
2010
1
-
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2
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1
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1
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1
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1
1
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695519
John
Identification and characteris ...
Mus musculus
Amino Acids
35
355-358
2008
-
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1
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1
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3
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1
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7
-
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1
1
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1
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1
1
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1
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7
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1
1
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697642
De Chaudhuri
Genetic variants associated wi ...
Homo sapiens
Environ. Health Perspect.
116
501-505
2008
-
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1
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1
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2
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1
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3
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1
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3
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697651
Yuan
Volatile arsenic species relea ...
Rhodopseudomonas palustris
Environ. Sci. Technol.
42
3201-3206
2008
-
-
1
-
-
-
-
-
-
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1
-
5
-
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1
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1
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1
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1
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1
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-
700331
Fujihara
Asian specific low mutation fr ...
Homo sapiens
Mutat. Res.
654
158-161
2008
-
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1
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1
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1
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2
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673463
Thomas
Arsenic (+3 oxidation state) m ...
Bos taurus, Ciona intestinalis, Gallus gallus, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, no activity in Drosophila melanogaster, Oncorhynchus mykiss, Pan troglodytes, Rattus norvegicus, Rhodopseudomonas palustris, Strongylocentrotus purpuratus
Exp. Biol. Med.
232
3-13
2007
4
-
10
-
-
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2
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2
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1
10
-
14
-
-
1
10
-
3
-
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18
1
2
-
-
-
2
-
-
10
-
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-
4
-
11
10
-
-
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2
-
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2
-
1
10
-
-
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1
-
3
-
-
18
1
2
-
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2
-
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-
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-
-
701300
Fujihara
Population differences in the ...
Homo sapiens
Toxicol. Appl. Pharmacol.
225
251-254
2007
-
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1
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1
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1
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2
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1
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