BRENDA - Enzyme Database
show all sequences of 2.1.1.137

Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals

Thomas, D.J.; Li, J.; Waters, S.B.; Xing, W.; Adair, B.M.; Drobna, Z.; Devesa, V.; Styblo, M.; Exp. Biol. Med. 232, 3-13 (2007)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Homo sapiens
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Rattus norvegicus
thioredoxin
dependent on, activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic
Homo sapiens
thioredoxin
activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic
Rattus norvegicus
Cloned(Commentary)
Cloned (Commentary)
Organism
expression of rat AS3MT in a simian virus 40 (SV40)-transformed human urothelial cell line confers the capacity to methylate inorganic arsenic on cells that otherwise do not express AS3MT and that have a null phenotype for iAs methylation; gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Rattus norvegicus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Bos taurus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Ciona intestinalis
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Gallus gallus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Mus musculus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Oncorhynchus mykiss
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Pan troglodytes
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Rhodopseudomonas palustris
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Strongylocentrotus purpuratus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT, recombinant expression
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Homo sapiens
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
x * 42000, SDS-PAGE
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Gallus gallus
enzyme evolutionary analysis
?
-
-
-
additional information
Mus musculus
enzyme evolutionary analysis
?
-
-
-
additional information
Rhodopseudomonas palustris
enzyme evolutionary analysis
?
-
-
-
additional information
Oncorhynchus mykiss
enzyme evolutionary analysis
?
-
-
-
additional information
Strongylocentrotus purpuratus
enzyme evolutionary analysis
?
-
-
-
additional information
Ciona intestinalis
enzyme evolutionary analysis
?
-
-
-
additional information
Pan troglodytes
enzyme evolutionary analysis
?
-
-
-
additional information
Rattus norvegicus
enzyme evolutionary analysis
?
-
-
-
additional information
Homo sapiens
enzyme evolutionary analysis
?
-
-
-
additional information
Bos taurus
enzyme evolutionary analysis
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
-
-
Bos taurus
Q58DQ0
gene arsM
-
Ciona intestinalis
-
; gene arsM
-
Gallus gallus
-
; gene arsM
-
Homo sapiens
Q9HBK9
; gene arsM
-
Mus musculus
-
; gene arsM
-
no activity in Caenorhabditis elegans
-
-
-
no activity in Drosophila melanogaster
-
-
-
Oncorhynchus mykiss
-
; gene arsM
-
Pan troglodytes
-
; gene arsM
-
Rattus norvegicus
Q8VHT6
adult male Fischer 344 rats, gene arsM
-
Rattus norvegicus
-
-
-
Rhodopseudomonas palustris
-
gene arsM
-
Strongylocentrotus purpuratus
-
gene arsM
-
Purification (Commentary)
Purification (Commentary)
Organism
native enzyme several thousandfold using pH-dependent fractionation, chromatofocusing, and S-adenosylhomocysteine-affinity chromatography, the purification of AS3MT from liver cytosol is dependent on the presence of 1 mM dithiothreitol and 5 mM GSH
Rattus norvegicus
Reaction
Reaction
Commentary
Organism
Reaction ID
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Bos taurus
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Ciona intestinalis
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Gallus gallus
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Homo sapiens
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Mus musculus
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Oncorhynchus mykiss
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Pan troglodytes
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Rattus norvegicus
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Rhodopseudomonas palustris
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
reaction modelling, overview
Strongylocentrotus purpuratus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
hepatocyte
primary
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
enzyme evolutionary analysis
673463
Gallus gallus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Mus musculus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Rhodopseudomonas palustris
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Oncorhynchus mykiss
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Strongylocentrotus purpuratus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Ciona intestinalis
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Pan troglodytes
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Rattus norvegicus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Homo sapiens
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Bos taurus
?
-
-
-
-
S-adenosyl-L-methionine + arsenite
-
673463
Gallus gallus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Mus musculus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Bos taurus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Oncorhynchus mykiss
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Ciona intestinalis
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Pan troglodytes
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 42000, SDS-PAGE
Rattus norvegicus
Synonyms
Synonyms
Commentary
Organism
arsenic (+3 oxidation state) methyltransferase
-
Bos taurus
arsenic (+3 oxidation state) methyltransferase
-
Ciona intestinalis
arsenic (+3 oxidation state) methyltransferase
-
Gallus gallus
arsenic (+3 oxidation state) methyltransferase
-
Mus musculus
arsenic (+3 oxidation state) methyltransferase
-
Oncorhynchus mykiss
arsenic (+3 oxidation state) methyltransferase
-
Pan troglodytes
arsenic (+3 oxidation state) methyltransferase
-
Rattus norvegicus
arsenic (+3 oxidation state) methyltransferase
-
Rhodopseudomonas palustris
arsenic (+3 oxidation state) methyltransferase
-
Strongylocentrotus purpuratus
arsenic (+3 oxidation state) methyltransferase
-
Homo sapiens
ArsM protein
-
Bos taurus
ArsM protein
-
Ciona intestinalis
ArsM protein
-
Gallus gallus
ArsM protein
-
Homo sapiens
ArsM protein
-
Mus musculus
ArsM protein
-
Oncorhynchus mykiss
ArsM protein
-
Pan troglodytes
ArsM protein
-
Rattus norvegicus
ArsM protein
-
Rhodopseudomonas palustris
ArsM protein
-
Strongylocentrotus purpuratus
AS3MT
-
Bos taurus
AS3MT
-
Ciona intestinalis
AS3MT
-
Gallus gallus
AS3MT
-
Mus musculus
AS3MT
-
Oncorhynchus mykiss
AS3MT
-
Pan troglodytes
AS3MT
-
Rattus norvegicus
AS3MT
-
Rhodopseudomonas palustris
AS3MT
-
Strongylocentrotus purpuratus
AS3MT
-
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
37
-
assay at
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
7.4
assay at
Homo sapiens
7
-
assay at
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Mus musculus
S-adenosyl-L-methionine
-
Homo sapiens
S-adenosyl-L-methionine
-
Rhodopseudomonas palustris
S-adenosyl-L-methionine
-
Bos taurus
S-adenosyl-L-methionine
-
Ciona intestinalis
S-adenosyl-L-methionine
-
Gallus gallus
S-adenosyl-L-methionine
-
Oncorhynchus mykiss
S-adenosyl-L-methionine
-
Pan troglodytes
S-adenosyl-L-methionine
-
Rattus norvegicus
S-adenosyl-L-methionine
-
Strongylocentrotus purpuratus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Homo sapiens
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Rattus norvegicus
thioredoxin
dependent on, activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic
Homo sapiens
thioredoxin
activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of rat AS3MT in a simian virus 40 (SV40)-transformed human urothelial cell line confers the capacity to methylate inorganic arsenic on cells that otherwise do not express AS3MT and that have a null phenotype for iAs methylation
Rattus norvegicus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Bos taurus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Ciona intestinalis
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Gallus gallus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Mus musculus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Oncorhynchus mykiss
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Pan troglodytes
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Rattus norvegicus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Rhodopseudomonas palustris
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT
Strongylocentrotus purpuratus
gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT, recombinant expression
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Mus musculus
S-adenosyl-L-methionine
-
Homo sapiens
S-adenosyl-L-methionine
-
Rhodopseudomonas palustris
S-adenosyl-L-methionine
-
Bos taurus
S-adenosyl-L-methionine
-
Ciona intestinalis
S-adenosyl-L-methionine
-
Gallus gallus
S-adenosyl-L-methionine
-
Oncorhynchus mykiss
S-adenosyl-L-methionine
-
Pan troglodytes
S-adenosyl-L-methionine
-
Rattus norvegicus
S-adenosyl-L-methionine
-
Strongylocentrotus purpuratus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Homo sapiens
GSH
addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
x * 42000, SDS-PAGE
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Gallus gallus
enzyme evolutionary analysis
?
-
-
-
additional information
Mus musculus
enzyme evolutionary analysis
?
-
-
-
additional information
Rhodopseudomonas palustris
enzyme evolutionary analysis
?
-
-
-
additional information
Oncorhynchus mykiss
enzyme evolutionary analysis
?
-
-
-
additional information
Strongylocentrotus purpuratus
enzyme evolutionary analysis
?
-
-
-
additional information
Ciona intestinalis
enzyme evolutionary analysis
?
-
-
-
additional information
Pan troglodytes
enzyme evolutionary analysis
?
-
-
-
additional information
Rattus norvegicus
enzyme evolutionary analysis
?
-
-
-
additional information
Homo sapiens
enzyme evolutionary analysis
?
-
-
-
additional information
Bos taurus
enzyme evolutionary analysis
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme several thousandfold using pH-dependent fractionation, chromatofocusing, and S-adenosylhomocysteine-affinity chromatography, the purification of AS3MT from liver cytosol is dependent on the presence of 1 mM dithiothreitol and 5 mM GSH
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
hepatocyte
primary
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
enzyme evolutionary analysis
673463
Gallus gallus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Mus musculus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Rhodopseudomonas palustris
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Oncorhynchus mykiss
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Strongylocentrotus purpuratus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Ciona intestinalis
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Pan troglodytes
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Rattus norvegicus
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Homo sapiens
?
-
-
-
-
additional information
enzyme evolutionary analysis
673463
Bos taurus
?
-
-
-
-
S-adenosyl-L-methionine + arsenite
-
673463
Gallus gallus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Mus musculus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Bos taurus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Oncorhynchus mykiss
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Ciona intestinalis
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Pan troglodytes
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
S-adenosyl-L-methionine + arsenite
-
673463
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 42000, SDS-PAGE
Rattus norvegicus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
7.4
assay at
Homo sapiens
7
-
assay at
Rattus norvegicus
Other publictions for EC 2.1.1.137
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733175
Zhang
Arsenic methylation and volati ...
Pseudomonas alcaligenes, Pseudomonas alcaligenes NBRC 14159
Appl. Environ. Microbiol.
81
2852-2860
2015
-
-
1
-
-
-
-
-
-
-
1
4
-
5
-
-
1
-
-
-
-
-
4
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
-
-
-
4
1
1
-
-
-
1
-
-
-
1
2
2
1
-
-
733887
Wang
Identification and catalytic r ...
Clostridium sp., Clostridium sp. BXM
FEMS Microbiol. Lett.
362(4)
1-8
2015
-
-
1
-
-
-
-
-
-
-
1
4
-
6
-
-
-
-
-
-
-
-
4
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733203
Ye
Identification and characteriz ...
Tetrahymena pyriformis
Aquat. Toxicol.
149
50-57
2014
-
-
1
-
-
-
-
-
-
-
2
3
-
5
-
-
1
-
-
-
-
-
3
1
3
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
1
-
-
-
-
3
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
733425
Li
Mutational analysis of residue ...
Homo sapiens
Biochimie
107 Pt B
396-405
2014
-
-
-
-
16
-
-
10
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
10
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733740
Wang
Identification and characteriz ...
Methanosarcina acetivorans
Environ. Sci. Technol.
48
12706-12713
2014
4
-
1
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735126
Wang
The functions of crucial cyste ...
Homo sapiens
PLoS ONE
9
e110924
2014
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735309
Tokumoto
-
Arsenic (+3 oxidation state) m ...
Homo sapiens
Toxicol. Rep.
1
589-595
2014
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
1
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733865
Li
Functional evaluation of Asp76 ...
Homo sapiens
FEBS Lett.
587
2232-2240
2013
-
-
1
-
8
-
-
2
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718946
Marapakala
Identification of catalytic re ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
944-951
2012
1
-
1
-
4
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
2
-
3
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
721074
Hamdi
Identification of an S-adenosy ...
Danio rerio
Toxicol. Appl. Pharmacol.
262
185-193
2012
-
-
1
-
2
-
2
-
-
-
1
-
-
6
-
-
1
-
-
10
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
2
-
-
-
-
1
-
-
-
-
1
-
10
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721075
Ding
Methylation of arsenic by reco ...
Homo sapiens
Toxicol. Appl. Pharmacol.
264
121-130
2012
1
-
1
-
1
-
1
7
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
7
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
733333
Ajees
Structure of an As(III) S-aden ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
5476-5485
2012
-
-
1
1
-
-
-
-
-
-
1
4
-
4
-
-
1
-
-
-
-
-
4
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733451
Sumi
Role of arsenic (+3 oxidation ...
Homo sapiens
Biol. Pharm. Bull.
35
1870-1875
2012
-
-
-
-
1
-
-
-
-
-
1
2
-
1
-
-
-
-
-
5
-
-
2
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
2
-
-
-
-
-
5
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733950
Huang
-
Crystallization and preliminar ...
Rhodopseudomonas palustris
He Jishu Nuclear Techniques
35
326-330
2012
-
-
1
1
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
734199
Wang
Rapid equilibrium kinetic anal ...
Homo sapiens
J. Biol. Chem.
287
38790-38799
2012
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718712
Fujihara
Genetic variants associated wi ...
Homo sapiens
Arch. Toxicol.
85
119-125
2011
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718748
Sumi
Alternative splicing variants ...
Homo sapiens
Biochem. Biophys. Res. Commun.
415
48-53
2011
-
-
1
-
1
-
-
-
-
-
2
-
-
3
-
-
1
-
-
5
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
1
-
5
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719012
Song
Functional and structural eval ...
Homo sapiens
Biochimie
93
369-375
2011
-
-
1
-
5
-
-
10
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
719007
Song
New insights into the mechanis ...
Homo sapiens
Biochimie
92
1397-1406
2010
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
695519
John
Identification and characteris ...
Mus musculus
Amino Acids
35
355-358
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
1
-
7
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697642
De Chaudhuri
Genetic variants associated wi ...
Homo sapiens
Environ. Health Perspect.
116
501-505
2008
-
-
1
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697651
Yuan
Volatile arsenic species relea ...
Rhodopseudomonas palustris
Environ. Sci. Technol.
42
3201-3206
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700331
Fujihara
Asian specific low mutation fr ...
Homo sapiens
Mutat. Res.
654
158-161
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673463
Thomas
Arsenic (+3 oxidation state) m ...
Bos taurus, Ciona intestinalis, Gallus gallus, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, no activity in Drosophila melanogaster, Oncorhynchus mykiss, Pan troglodytes, Rattus norvegicus, Rhodopseudomonas palustris, Strongylocentrotus purpuratus
Exp. Biol. Med.
232
3-13
2007
4
-
10
-
-
-
2
-
2
-
1
10
-
14
-
-
1
10
-
3
-
-
18
1
34
2
-
-
-
2
-
-
10
-
-
-
4
-
11
10
-
-
-
-
2
-
-
2
-
1
10
-
-
-
1
-
3
-
-
18
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
701300
Fujihara
Population differences in the ...
Homo sapiens
Toxicol. Appl. Pharmacol.
225
251-254
2007
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673066
Drobna
shRNA silencing of AS3MT expre ...
Homo sapiens
Chem. Res. Toxicol.
19
894-898
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674763
Wood
Human arsenic methyltransferas ...
Homo sapiens
J. Biol. Chem.
281
7364-7373
2006
-
-
1
-
-
-
-
6
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676841
Qin
Arsenic detoxification and evo ...
Rhodopseudomonas palustris, Rhodopseudomonas palustris CGA009
Proc. Natl. Acad. Sci. USA
103
2075-2080
2006
-
-
1
-
-
-
-
-
-
-
-
2
-
10
-
-
1
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657702
Hayakawa
A new metabolic pathway of ars ...
Homo sapiens
Arch. Toxicol.
79
183-191
2005
1
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677192
Drobna
Metabolism and toxicity of ars ...
Rattus norvegicus
Toxicol. Appl. Pharmacol.
207
147-159
2005
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658444
Waters
Glutathione modulates recombin ...
Rattus norvegicus
Chem. Res. Toxicol.
17
1621-1629
2004
1
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658442
Walton
Selenium compounds modulate th ...
Homo sapiens, Rattus norvegicus
Chem. Res. Toxicol.
16
261-265
2003
4
-
-
-
-
-
8
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
8
2
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659168
Lin
A novel S-adenosyl-L-methionin ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
277
10795-10803
2002
-
-
-
-
-
-
-
-
2
-
-
-
-
5
-
-
1
-
-
10
1
-
2
-
4
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
10
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
660549
Wildfang
Enzymatic methylation of arsen ...
Macaca fascicularis, Macaca mulatta, Macaca nemestrina, no activity in Aotus sp., no activity in Callithrix jacchus, no activity in Cheirogaleus medius, no activity in Daubentonia madagascariensis, no activity in Galago senegalensis, no activity in Gorilla gorilla, no activity in Lemur catta, no activity in Nycticebus coucang, no activity in Pan troglodytes, no activity in Papio cynocephalus, no activity in Pongo pygmaeus, no activity in Propithecus verreauxi, no activity in Saguinus oedipus, Saimiri sp.
Toxicology
168
213-221
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
27
-
-
-
-
-
4
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485148
Wildfang
Enzymatic methylation of arsen ...
Cricetinae
Toxicol. Appl. Pharmacol.
152
366-375
1998
3
-
-
-
-
-
-
1
1
-
1
1
-
4
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
1
1
-
1
1
-
-
-
1
-
1
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485149
Healey
Enzymatic methylation of arsen ...
Mus musculus
Toxicol. Appl. Pharmacol.
148
65-70
1998
-
-
-
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
8
4
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
8
4
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485150
Healy S.M.; Zakharyan
Enzymatic methylation of arsen ...
no activity in Cavia porcellus
Mutat. Res.
386
229-239
1997
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485151
Zakharyan
Enzymatic methylation of arsen ...
Macaca mulatta, no activity in Callithrix jacchus, no activity in Saguinus oedipus, Oryctolagus cuniculus
Toxicol. Appl. Pharmacol.
140
77-84
1996
-
-
-
-
-
-
-
2
2
-
-
2
-
4
-
-
1
-
-
2
1
-
2
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
2
-
-
2
-
-
-
1
-
2
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485152
Zakharyan
Enzymatic methylation of arsen ...
Oryctolagus cuniculus
Chem. Res. Toxicol.
8
1029-1038
1995
3
-
-
-
-
-
3
-
1
-
1
1
-
2
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
3
-
-
1
-
-
-
-
3
-
-
1
-
1
1
-
-
-
1
-
1
1
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-