BRENDA - Enzyme Database show
show all sequences of 2.1.1.137

Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver

Zakharyan, R.; Wu, Y.; Bogdan, G.M.; Aposhian, H.V.; Chem. Res. Toxicol. 8, 1029-1038 (1995)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
dithiothreitol
-
Oryctolagus cuniculus
glutathione
-
Oryctolagus cuniculus
L-cysteine
-
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
HgCl2
-
Oryctolagus cuniculus
selenate
more than 1 mM selenate necessary for 50% inhibition
Oryctolagus cuniculus
Selenite
50% inhibition with 0.0126 mM selinite
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Oryctolagus cuniculus
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
60000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + arsenite
Oryctolagus cuniculus
-
S-adenosyl-L-homocysteine + methylarsonate
-
Oryctolagus cuniculus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
DEAE cellulose, ammonium sulfate precipitation, Sephadex G-200, Sephadex G-100, 2000fold purification
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.00000167
-
-
Oryctolagus cuniculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + arsenite
-
485152
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + methylarsonate
-
485152
Oryctolagus cuniculus
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
optimum if enzyme activity is measured in crude extracts
Oryctolagus cuniculus
8.2
-
-
Oryctolagus cuniculus
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
dithiothreitol
-
Oryctolagus cuniculus
glutathione
-
Oryctolagus cuniculus
L-cysteine
-
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
HgCl2
-
Oryctolagus cuniculus
selenate
more than 1 mM selenate necessary for 50% inhibition
Oryctolagus cuniculus
Selenite
50% inhibition with 0.0126 mM selinite
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Oryctolagus cuniculus
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
60000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + arsenite
Oryctolagus cuniculus
-
S-adenosyl-L-homocysteine + methylarsonate
-
Oryctolagus cuniculus
?
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE cellulose, ammonium sulfate precipitation, Sephadex G-200, Sephadex G-100, 2000fold purification
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.00000167
-
-
Oryctolagus cuniculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + arsenite
-
485152
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + methylarsonate
-
485152
Oryctolagus cuniculus
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
optimum if enzyme activity is measured in crude extracts
Oryctolagus cuniculus
8.2
-
-
Oryctolagus cuniculus
Other publictions for EC 2.1.1.137
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733175
Zhang
Arsenic methylation and volati ...
Pseudomonas alcaligenes, Pseudomonas alcaligenes NBRC 14159
Appl. Environ. Microbiol.
81
2852-2860
2015
-
-
1
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1
4
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1
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1
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1
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4
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1
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4
1
1
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1
-
-
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1
2
2
1
-
-
733887
Wang
Identification and catalytic r ...
Clostridium sp., Clostridium sp. BXM
FEMS Microbiol. Lett.
362(4)
1-8
2015
-
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1
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1
4
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4
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4
1
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733203
Ye
Identification and characteriz ...
Tetrahymena pyriformis
Aquat. Toxicol.
149
50-57
2014
-
-
1
-
-
-
-
-
-
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2
3
-
5
-
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1
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1
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1
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3
1
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1
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1
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733425
Li
Mutational analysis of residue ...
Homo sapiens
Biochimie
107 Pt B
396-405
2014
-
-
-
-
16
-
-
10
-
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1
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2
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1
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16
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10
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1
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1
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733740
Wang
Identification and characteriz ...
Methanosarcina acetivorans
Environ. Sci. Technol.
48
12706-12713
2014
4
-
1
-
-
-
-
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2
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5
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735126
Wang
The functions of crucial cyste ...
Homo sapiens
PLoS ONE
9
e110924
2014
-
-
1
-
1
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1
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2
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1
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1
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1
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735309
Tokumoto
Arsenic (+3 oxidation state) m ...
Homo sapiens
Toxicol. Rep.
1
589-595
2014
-
-
1
-
-
-
-
-
-
-
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2
-
1
-
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1
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1
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1
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3
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733865
Li
Functional evaluation of Asp76 ...
Homo sapiens
FEBS Lett.
587
2232-2240
2013
-
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1
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8
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2
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2
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718946
Marapakala
Identification of catalytic re ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
944-951
2012
1
-
1
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4
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5
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1
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2
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1
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721074
Hamdi
Identification of an S-adenosy ...
Danio rerio
Toxicol. Appl. Pharmacol.
262
185-193
2012
-
-
1
-
2
-
2
-
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1
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6
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1
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10
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1
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10
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1
1
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721075
Ding
Methylation of arsenic by reco ...
Homo sapiens
Toxicol. Appl. Pharmacol.
264
121-130
2012
1
-
1
-
1
-
1
7
-
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2
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1
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2
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7
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1
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2
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1
1
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733333
Ajees
Structure of an As(III) S-aden ...
Cyanidioschyzon sp., Cyanidioschyzon sp. 5508
Biochemistry
51
5476-5485
2012
-
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1
1
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1
4
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4
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1
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1
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1
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733451
Sumi
Role of arsenic (+3 oxidation ...
Homo sapiens
Biol. Pharm. Bull.
35
1870-1875
2012
-
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1
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2
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1
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5
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1
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733950
Huang
-
Crystallization and preliminar ...
Rhodopseudomonas palustris
He Jishu Nuclear Techniques
35
326-330
2012
-
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1
1
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2
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1
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734199
Wang
Rapid equilibrium kinetic anal ...
Homo sapiens
J. Biol. Chem.
287
38790-38799
2012
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1
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2
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718712
Fujihara
Genetic variants associated wi ...
Homo sapiens
Arch. Toxicol.
85
119-125
2011
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1
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2
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1
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718748
Sumi
Alternative splicing variants ...
Homo sapiens
Biochem. Biophys. Res. Commun.
415
48-53
2011
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1
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1
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2
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5
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1
1
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1
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719012
Song
Functional and structural eval ...
Homo sapiens
Biochimie
93
369-375
2011
-
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1
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5
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10
-
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3
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1
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5
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10
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1
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1
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719007
Song
New insights into the mechanis ...
Homo sapiens
Biochimie
92
1397-1406
2010
1
-
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2
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1
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1
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1
1
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695519
John
Identification and characteris ...
Mus musculus
Amino Acids
35
355-358
2008
-
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1
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1
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3
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1
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7
-
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1
1
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1
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1
1
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1
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7
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1
1
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697642
De Chaudhuri
Genetic variants associated wi ...
Homo sapiens
Environ. Health Perspect.
116
501-505
2008
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1
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1
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2
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1
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1
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697651
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Volatile arsenic species relea ...
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2008
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1
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1
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Fujihara
Asian specific low mutation fr ...
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1
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673463
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Arsenic (+3 oxidation state) m ...
Bos taurus, Ciona intestinalis, Gallus gallus, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, no activity in Drosophila melanogaster, Oncorhynchus mykiss, Pan troglodytes, Rattus norvegicus, Rhodopseudomonas palustris, Strongylocentrotus purpuratus
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18
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2
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4
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11
10
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2
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1
10
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1
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3
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18
1
2
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Population differences in the ...
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2007
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1
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673066
Drobna
shRNA silencing of AS3MT expre ...
Homo sapiens
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19
894-898
2006
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2
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Human arsenic methyltransferas ...
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6
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2
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676841
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Arsenic detoxification and evo ...
Rhodopseudomonas palustris, Rhodopseudomonas palustris CGA009
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103
2075-2080
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1
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4
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657702
Hayakawa
A new metabolic pathway of ars ...
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1
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1
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3
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Drobna
Metabolism and toxicity of ars ...
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1
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658444
Waters
Glutathione modulates recombin ...
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2004
1
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2
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658442
Walton
Selenium compounds modulate th ...
Homo sapiens, Rattus norvegicus
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2003
4
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2
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Lin
A novel S-adenosyl-L-methionin ...
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1
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1
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1
1
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660549
Wildfang
Enzymatic methylation of arsen ...
Macaca fascicularis, Macaca mulatta, Macaca nemestrina, no activity in Aotus sp., no activity in Callithrix jacchus, no activity in Cheirogaleus medius, no activity in Daubentonia madagascariensis, no activity in Galago senegalensis, no activity in Gorilla gorilla, no activity in Lemur catta, no activity in Nycticebus coucang, no activity in Pan troglodytes, no activity in Papio cynocephalus, no activity in Pongo pygmaeus, no activity in Propithecus verreauxi, no activity in Saguinus oedipus, Saimiri sp.
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3
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Enzymatic methylation of arsen ...
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3
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1
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1
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1
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1
1
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1
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Enzymatic methylation of arsen ...
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4
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Enzymatic methylation of arsen ...
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Enzymatic methylation of arsen ...
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Enzymatic methylation of arsen ...
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1
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1
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1
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1
1
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1
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