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Literature summary for 2.1.1.130 extracted from

  • Roessner, C.A.; Huang, K.X.; Warren, M.J.; Raux, E.; Scott, A.I.
    Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. Shermanii) (2002), Microbiology, 148, 1845-1853.
    View publication on PubMed
Search for more literature for 2.1.1.130

Cloned(Commentary)

Cloned (Comment) Organism
gene cbiL, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Salmonella enterica subsp. enterica serovar Typhimurium
gene cbiL, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview Propionibacterium freudenreichii

Protein Variants

Protein Variants Comment Organism
additional information complementation with gene cbiL of Propionibacterium freudenreichii of 2 mutants AR3711 and AR3717 of an engineered Escherichia coli strain that synthesizes cobinamide using the Salmonella typhimurium cbi genes Propionibacterium freudenreichii
additional information complementation with gene cbiL of Propionibacterium freudenreichii of 2 mutants AR3711 and AR3717 of an engineered Escherichia coli strain that synthesizes cobinamide using the Salmonella typhimurium cbi genes, overview Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas denitrificans (nom. rej.) the organism performs the aerobic cobalamin biosynthesis variant ?
-
 ?
additional information Salmonella enterica subsp. enterica serovar Typhimurium the organism performs the anaerobic cobalamin biosynthesis variant ?
-
 ?
additional information Propionibacterium freudenreichii the organism performs the anaerobic cobalamin biosynthesis variant ?
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 Salmonella enterica subsp. enterica serovar Typhimurium enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 Pseudomonas denitrificans (nom. rej.) enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 Propionibacterium freudenreichii enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?

Organism

Organism UniProt Comment Textmining
Propionibacterium freudenreichii
-
 i.e. Propionibacterium shermanii, gene cbiL
-
Pseudomonas denitrificans (nom. rej.)
-
 gene cobI
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 gene cbiL
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the organism performs the aerobic cobalamin biosynthesis variant Pseudomonas denitrificans (nom. rej.) ?
-
 ?
additional information the organism performs the anaerobic cobalamin biosynthesis variant Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
additional information the organism performs the anaerobic cobalamin biosynthesis variant Propionibacterium freudenreichii ?
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, overview Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 enzyme is involved in anaerobic cobalamin, i.e. vitamin B12, biosynthesis, pathway overview Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Pseudomonas denitrificans (nom. rej.) S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?
S-adenosyl-L-methionine + cobalt-precorrin-2 methylation at C-20 Propionibacterium freudenreichii S-adenosyl-L-homocysteine + cobalt-precorrin-3A
-
 ?

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
S-adenosyl-L-methionine
-
 Pseudomonas denitrificans (nom. rej.)
S-adenosyl-L-methionine
-
 Propionibacterium freudenreichii