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Literature summary for 2.1.1.13 extracted from

  • Kozlowski, P.M.; Kamachi, T.; Kumar, M.; Yoshizawa, K.
    Reductive elimination pathway for homocysteine to methionine conversion in cobalamin-dependent methionine synthase (2012), J. Biol. Inorg. Chem., 17, 611-619.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli P13009
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the activation barrier for the reductive elimination reaction (24.4 kcal per mol) is almost four times higher than that for the SN2 reaction (7.3 kcal per mol). This energy demand is rooted in the structural distortion of the corrin ring that is induced en route to the formation of the triangular transition state. The reductive elimination reaction demands the syn accommodation of the methyl group and the substrate over the upper face of the corrin ring, which also accounts for the high energy demand of the reaction. Therefore the reductive elimination pathway for MetH-catalyzed methyl transfer cannot be considered as one of the possible mechanistic routes Escherichia coli ?
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Synonyms

Synonyms Comment Organism
MetH
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Escherichia coli