Literature summary for 2.1.1.128 extracted from

Desgagne-Penix, I.; Facchini, P.
Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy (2012), Plant J., 72, 331-344.

Search for more literature for 2.1.1.128

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	-	opium poppy, cultivar Bea's Choice	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + (S)-norcoclaurine	preferred substrate	Papaver somniferum	S-adenosyl-L-homocysteine + (S)-coclaurine	-	?
S-adenosyl-L-methionine + (S)-norlaudanosoline	-	Papaver somniferum	S-adenosyl-L-homocysteine + 6-O-methylnorlaudanosoline	-	?

Synonyms

Synonyms	Comment	Organism
(S)-norcoclaurine 6-O-methyltransferase	-	Papaver somniferum
6OMT	-	Papaver somniferum
Norcoclaurine 6-O-methyltransferase	-	Papaver somniferum

General Information

General Information	Comment	Organism
malfunction	suppression of norcoclaurine 6-O-methyltransferase transcript levels significantly suppresses total alkaloid accumulation in opium poppy (73% compared to the controls). However, the relative abundance of morphine increased to 55% of the total alkaloid content. Suppression of the enzyme does not significantly affect (S)-3'-hydroxy-N-methylcoclaurine 1 or (S)-3'-hydroxy-N-methylcoclaurine 2 transcript levels	Papaver somniferum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)