Literature summary for 2.1.1.128 extracted from

Apuya, N.R.; Park, J.H.; Zhang, L.; Ahyow, M.; Davidow, P.; Van Fleet, J.; Rarang, J.C.; Hippley, M.; Johnson, T.W.; Yoo, H.D.; Trieu, A.; Krueger, S.; Wu, C.Y.; Lu, Y.P.; Flavell, R.B.; Bobzin, S.C.
Enhancement of alkaloid production in opium and California poppy by transactivation using heterologous regulatory factors (2008), Plant Biotechnol. J., 6, 160-175.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + (RS)-norcoclaurine	Papaver somniferum	-	S-adenosyl-L-homocysteine + (RS)-coclaurine	-	?

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + (RS)-norcoclaurine	-	Papaver somniferum	S-adenosyl-L-homocysteine + (RS)-coclaurine	-	?

Synonyms

Synonyms	Comment	Organism
(R,S)-norcoclaurine 6-O-methyltransferase	-	Papaver somniferum
Ps6OMT	-	Papaver somniferum

Expression

Organism	Comment	Expression
Papaver somniferum	the over-expression of regulatory factors AP2G, AN1-like, ERF2, GARP, MDB025 and WRKY1 increases the levels of codeinone reductase, (S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase) and (R,S)-norcoclaurine 6-O-methyltransferase transcripts by 10- to more than 100fold. The transcriptional activations translate into an enhancement of alkaloid production in opium poppy of up to at least 10fold	up

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Release 2023.1 (January 2023)