Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione | i.e. NSC-668394 | Haemonchus contortus | |
NSC-641296 | compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM); compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM) | Haemonchus contortus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemonchus contortus | A0A2Z1FIB9 | - |
- |
Haemonchus contortus | U5HK48 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine | Haemonchus contortus | ? | - |
- |
|
additional information | isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step | Haemonchus contortus | ? | - |
- |
|
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine | - |
Haemonchus contortus | choline phosphate + S-adenosyl-L-homocysteine | - |
? | |
N-methylethanolamine phosphate + S-adenosyl-L-methionine | - |
Haemonchus contortus | N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine | - |
? | |
S-adenosyl-L-methionine + ethanolamine phosphate | - |
Haemonchus contortus | S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PMT1 | - |
Haemonchus contortus |
PMT2 | - |
Haemonchus contortus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0028 | - |
combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication | Haemonchus contortus | 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione | |
0.0051 | - |
combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication | Haemonchus contortus | NSC-641296 | |
0.0059 | - |
isoform PMT1 alone, 24°C, pH not specified in the publication | Haemonchus contortus | 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione | |
0.0083 | - |
isoform PMT1 alone, 24°C, pH not specified in the publication | Haemonchus contortus | NSC-641296 |