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Literature summary for 2.1.1.103 extracted from

  • Lee, S.G.; Alpert, T.D.; Jez, J.M.
    Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine (2012), Bioorg. Med. Chem. Lett., 22, 4990-4993.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.103

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with amodiaquine, hanging drop vapor diffusion method Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
amodiaquine i.e. 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Plasmodium falciparum
Chloroquine
-
 Plasmodium falciparum
primaquine
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + ethanolamine phosphate Plasmodium falciparum
-
 S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q6T755
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphoethanolamine methyltransferase
-
 Plasmodium falciparum
PMT
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.46
-
 pH and temperature not specified in the publication Plasmodium falciparum primaquine
0.554
-
 pH and temperature not specified in the publication Plasmodium falciparum Chloroquine
1.35
-
 pH and temperature not specified in the publication Plasmodium falciparum amodiaquine