Literature summary for 2.1.1.100 extracted from

Zhu, Y.; Hu, Q.; Li, H.
Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation (2019), Biochem. Biophys. Res. Commun., 516, 784-789 .

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Application

Application	Comment	Organism
medicine	Icmt mRNA and protein levels are increased in nasopharyngeal carcinoma cells after prolonged exposure to chemotherapy. Icmt inhibition is more effective against chemoresistant compared to chemosensitive nasopharyngeal carcinoma cells. The combination of Icmt inhibition with 5-fluorouracil or cisplatin results in greater efficacy than single chemotherapeutic agent alone in nasopharyngeal carcinoma cells. Icmt inhibition decreases Ras and RhoA activities, Ras may be the critical effector of Icmt in nasopharyngeal carcinoma cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	A0A024R4F6	-	-

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Release 2023.1 (January 2023)