Literature summary for 2.1.1.100 extracted from

Liu, Q.; Chen, J.; Fu, B.; Dai, J.; Zhao, Y.; Lai, L.
Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation (2018), Biochem. Biophys. Res. Commun., 501, 556-562 .

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Application

Application	Comment	Organism
medicine	upregulation of Icmt expression is a common feature in patients with epithelial ovarian cancer regardless of age and disease stage. Ovarian cancer cell lines with higher Icmt levels are more resistant to chemotherapeutic agents. Icmt inhibition by siRNA or inhibitor cysmethynil suppresses growth and induces apoptosis in ovarian cancer cells. Icmt inhibition significantly augments chemotherapeutic agent's efficacy in vitro and in vivo. Ras activation is a critical effector of ICT in ovarian cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	A0A024R4F6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary epithelium	IHOEC cell, immortalized human ovarian epithelial cell	Homo sapiens	-
ovary epithelium	HPOVEC cell, primary ovarian surface epithelial cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Icmt	-	Homo sapiens

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Release 2023.1 (January 2023)