Cloned (Comment) | Organism |
---|---|
expressed in Spodoptera frugiperda ovarian membranes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanol | - |
Homo sapiens | |
3-(2,2-dimethyloxan-4-yl)-N-[(4-methoxyphenyl)methyl]-3-phenylpropan-1-amine | - |
Homo sapiens | |
3-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]phenol | - |
Homo sapiens | |
4-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N-methylbenzene-1-sulfonamide | - |
Homo sapiens | |
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N,N-dimethylpyridin-2-amine | - |
Homo sapiens | |
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidin-2-amine | - |
Homo sapiens | |
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
cysmethynil | - |
Homo sapiens | |
methyl 3-[[(2E)-5-[4-[2-([1,1'-biphenyl]-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate | - |
Homo sapiens | |
N-(2-phenoxybenzoyl)-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | - |
Homo sapiens | |
N-ethyl-N-([1-octyl-5-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl)ethanamine | - |
Homo sapiens | |
N-ethyl-N-([5-[4-(methanesulfonyl)phenyl]-1-octyl-1H-indol-3-yl]methyl)ethanamine | - |
Homo sapiens | |
N-ethyl-N-[(4-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[(6-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[(7-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[1-octyl-5-(pyridin-3-yl)-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[1-octyl-5-(pyrimidin-5-yl)-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[5-(2-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[5-(3-fluoropyridin-4-yl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | - |
Homo sapiens | |
S-[(2E)-3-[2-([1,1'-biphenyl]-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl]-N-(2-phenoxybenzoyl)-L-cysteine | - |
Homo sapiens | |
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
IMR-90 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Mia PACA 2 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
isoprenylcysteine carboxyl methyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00086 | - |
at pH 7.4 and 37°C | Homo sapiens | 5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidin-2-amine | |
0.00096 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[5-(3-fluoropyridin-4-yl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | |
0.00158 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[1-octyl-5-(pyrimidin-5-yl)-1H-indol-3-yl]methyl]ethanamine | |
0.00161 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | |
0.00163 | - |
at pH 7.4 and 37°C | Homo sapiens | 5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N,N-dimethylpyridin-2-amine | |
0.00171 | - |
at pH 7.4 and 37°C | Homo sapiens | 4-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N-methylbenzene-1-sulfonamide | |
0.00172 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-([5-[4-(methanesulfonyl)phenyl]-1-octyl-1H-indol-3-yl]methyl)ethanamine | |
0.00175 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[1-octyl-5-(pyridin-3-yl)-1H-indol-3-yl]methyl]ethanamine | |
0.0019 | - |
at pH 7.4 and 37°C | Homo sapiens | cysmethynil | |
0.00218 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | |
0.00222 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[(6-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | |
0.00226 | - |
at pH 7.4 and 37°C | Homo sapiens | 5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidine-2-carbonitrile | |
0.00227 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[(7-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | |
0.00245 | - |
at pH 7.4 and 37°C | Homo sapiens | 3-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]phenol | |
0.00256 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[[5-(2-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine | |
0.00261 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-([1-octyl-5-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl)ethanamine | |
0.00442 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[(4-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | |
0.00483 | - |
at pH 7.4 and 37°C | Homo sapiens | N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine | |
0.00543 | - |
at pH 7.4 and 37°C | Homo sapiens | S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in the posttranslational modification of proteins involved in the regulation of cell growth and oncogenesis | Homo sapiens |