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Literature summary for 2.1.1.100 extracted from

  • Hahne, K.; Vervacke, J.S.; Shrestha, L.; Donelson, J.L.; Gibbs, R.A.; Distefano, M.D.; Hrycyna, C.A.
    Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes (2012), Biochem. Biophys. Res. Commun., 423, 98-103.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.100

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
-
 Saccharomyces cerevisiae
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
-
 Saccharomyces cerevisiae
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
-
 Saccharomyces cerevisiae
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
 S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine at pH 7.5 and 25°C Homo sapiens
0.0051
-
 biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp) at pH 7.5 and 25°C Homo sapiens
0.0059
-
 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine at pH 7.5 and 25°C Homo sapiens
0.0061
-
 biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp) IC50 above 0.1 mM, at pH 7.5 and 25°C Homo sapiens
0.0103
-
 N-acetyl-S-farnesyl-L-cysteine at pH 7.5 and 25°C Saccharomyces cerevisiae
0.0146
-
 biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp) IC50 above 0.1 mM, at pH 7.5 and 25°C Homo sapiens
0.015
-
 biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp) at pH 7.5 and 25°C Homo sapiens
0.0159
-
 N-acetyl-S-farnesyl-L-cysteine at pH 7.5 and 25°C Homo sapiens
0.0179
-
 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine at pH 7.5 and 25°C Saccharomyces cerevisiae
0.0183
-
 S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine at pH 7.5 and 25°C Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
-
 Homo sapiens 5789
-
endoplasmic reticulum membrane
-
 Saccharomyces cerevisiae 5789
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 x * 26000, SDS-PAGE Saccharomyces cerevisiae
33000
-
 x * 33000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Homo sapiens
-
 S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine Homo sapiens
-
 S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
-
 Saccharomyces cerevisiae ?
-
 ?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Subunits

Subunits Comment Organism
? x * 26000, SDS-PAGE Saccharomyces cerevisiae
? x * 33000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Icmt
-
 Homo sapiens
Icmt
-
 Saccharomyces cerevisiae
isoprenylcysteine carboxyl methyltransferase
-
 Homo sapiens
isoprenylcysteine carboxyl methyltransferase
-
 Saccharomyces cerevisiae
Ste14p
-
 Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0137
-
 at pH 7.5 and 25°C Saccharomyces cerevisiae biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
0.0257
-
 at pH 7.5 and 25°C Saccharomyces cerevisiae biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
0.1
-
 IC50 above 0.1 mM, at pH 7.5 and 25°C Saccharomyces cerevisiae biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
0.1
-
 IC50 above 0.1 mM, at pH 7.5 and 25°C Saccharomyces cerevisiae biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)