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Literature summary for 2.1.1.100 extracted from

  • Cushman, I.; Casey, P.J.
    RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion (2011), Cell Adh. Migr., 5, 11-15.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane an integral membrane protein Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
Homo sapiens S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?

Synonyms

Synonyms Comment Organism
Icmt
-
Homo sapiens
isoprenylcysteine carboxylmethyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction cell migration and adhesion are impaired by enzyme inhibition (the actin cytoskeleton remains unorganized and lacks peripgeral actin filaments and stress fiber formation in the interior of the cell) Homo sapiens
physiological function isoprenylcysteine carboxylmethyltransferase plays a role in cell migration and adhesion Homo sapiens