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Literature summary for 2.1.1.100 extracted from

  • Cushman, I.; Casey, P.J.
    Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration (2009), J. Biol. Chem., 284, 27964-27973.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout by siRNA in MDA-MB 231 cells, phenotype, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-octyl-5-(3-methylphenyl)-1H-indole a cysmethynil analogue Homo sapiens
cysmethynil specific inhibitor, is also able to inhibit Ras-mediated signaling, cell growth, and oncogenesis, and it affects cell adhesion and cell spreading Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inhibition of Icmt significantly decreases the activation of both RhoA and Rac1 involving Rho GDP-dissociation inhibitor, RhoGDI, overview. Icmt inhibition impairs RhoGTPase activation ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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Homo sapiens
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MDA-MB-231 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inhibition of Icmt significantly decreases the activation of both RhoA and Rac1 involving Rho GDP-dissociation inhibitor, RhoGDI, overview. Icmt inhibition impairs RhoGTPase activation Homo sapiens ?
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?
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine
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Homo sapiens S-adenosyl-L-homocysteine + N-biotinyl-S-farnesyl-L-cysteine methyl ester
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?

Synonyms

Synonyms Comment Organism
Icmt
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Homo sapiens
isoprenylcysteine carboxylmethyltransferase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
metabolism methylation of the C-terminus by Icmt is the final step in the prenylation pathway. The prenylation pathway consists of three enzymatic steps, the final processed protein is isoprenoid modified and methylated on the C-terminal cysteine. This protein modification pathway plays a significant role in cancer biology because many oncogenic proteins undergo prenylation Homo sapiens