Literature summary for 2.1.1.100 extracted from

Hasne, M.P.; Lawrence, F.
Characterization of prenylated protein methyltransferase in Leishmania (1999), Biochem. J., 342, 513-518.

No PubMed abstract available

Search for more literature for 2.1.1.100

Activating Compound

Activating Compound	Comment	Organism	Structure
guanosine 5'-[gamma-thio]-triphosphate	stimulation of carboxymethylation of endogenous substrates	Leishmania donovani
additional information	no increase in N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation	Leishmania donovani

Inhibitors

Inhibitors	Comment	Organism	Structure
methylthioadenosine	0.9 mM, 50% inhibition	Leishmania donovani
S-adenosyl-L-homocysteine	0.025 mM; 50% inhibition	Leishmania donovani
S-farnesyl thiosalicylic acid	0.05 mM, 50% inhibition	Leishmania donovani
sinefungin	0.00002 mM; 50% inhibition, competitive vs. S-adenosyl-L-methionine	Leishmania donovani

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00013	-	S-adenosyl-L-methionine	-	Leishmania donovani
0.06	-	N-acetyl-S-(E,E)-farnesyl-L-cysteine	-	Leishmania donovani
0.166	-	N-acetyl-S-geranylgeranyl-L-cysteine	-	Leishmania donovani

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine	-	Leishmania donovani	S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester	-	?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine	-	Leishmania donovani	S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester	-	?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine	-	Leishmania donovani	S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	8	-	Leishmania donovani

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Release 2023.1 (January 2023)