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Literature summary for 2.1.1.100 extracted from

  • Ma, Y.T.; Shi, Y.Q.; Lim, Y.H.; McGrail, S.H.; Ware, J.A.; Rando, R.R.
    Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase (1994), Biochemistry, 33, 5414-5420.
    View publication on PubMed
Search for more literature for 2.1.1.100

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-S-farnesyl-L-cysteine methyl ester
-
 Homo sapiens
S-adenosyl-L-homocysteine
-
 Homo sapiens
S-Farnesylthioacetic acid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00255
-
 N-(benzoylglycyl)-S-farnesyl-L-cysteine
-
 Homo sapiens
0.00255
-
 N-isovaleryl-S-farnesyl-L-cysteine
-
 Homo sapiens
0.00295
-
 N-isobutyryl-S-farnesyl-L-cysteine
-
 Homo sapiens
0.0105
-
 N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester ordered bi bi mechanism, S-adenosyl-L-methionine binds first, S-adenosyl-L-homocysteine departs last Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosylmethionine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosylhomocysteine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosylmethionine + N-(benzoylglycyl)-S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosylhomocysteine + N-(benzoylglycyl)-S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosylmethionine + N-isobutyryl-S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosylhomocysteine + N-isobutyryl-S-farnesyl-L-cysteine methyl ester
-
 ?
S-adenosylmethionine + N-isovaleryl-S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosylhomocysteine + N-isovaleryl-S-farnesyl-L-cysteine methyl ester
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00207
-
 N-acetyl-S-farnesyl-L-cysteine methyl ester mixed-type vs. N-acetyl-S-farnesyl-L-cysteine Homo sapiens
0.00413
-
 S-adenosyl-L-homocysteine competitive vs. S-adenosyl-L-methionine Homo sapiens
0.0044
-
 S-adenosyl-L-homocysteine mixed-type vs. N-acetyl-S-farnesyl-L-cysteine Homo sapiens
0.005
-
 N-acetyl-S-farnesyl-L-cysteine methyl ester competitive vs. S-adenosyl-L-methionine Homo sapiens
0.0137
-
 S-Farnesylthioacetic acid competitive vs. N-acetyl-S-farnesyl-L-cysteine Homo sapiens