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Literature summary for 2.1.1.100 extracted from

  • Giner, J.L.; Rando, R.R.
    Novel methyltransferase activity modifying the carboxy terminal bis(geranylgeranyl)-Cys-Ala-Cys structure of small GTP-binding proteins (1994), Biochemistry, 33, 15116-15123.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
Bos taurus
S-adenosylethionine
-
Bos taurus
S-Farnesylthioacetic acid
-
Bos taurus
sinefungin
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
S-adenosyl-L-methionine
-
Bos taurus
0.0565
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Bos taurus
0.594
-
N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Bos taurus 16020
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-
heart
-
Bos taurus
-
intestine
-
Bos taurus
-
kidney
-
Bos taurus
-
liver
-
Bos taurus
-
lung
-
Bos taurus
-
retina
-
Bos taurus
-
retinal rod outer segment Bos taurus
-
testis
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine no activity with + N-acetyl-S-geranylgeranyl-L-cysteinyl-S-geranylgeranyl-L-cysteine Bos taurus S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000296
-
sinefungin inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus
0.000318
-
sinefungin inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
0.00645
-
S-adenosylethionine inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
0.00658
-
S-adenosyl-L-homocysteine inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
0.0112
-
S-Farnesylthioacetic acid inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
0.0115
-
S-adenosyl-L-homocysteine inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus
0.0218
-
S-adenosylethionine inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus