Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | P34254 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ANMT-1 | - |
Caenorhabditis elegans |
B0303.2 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | ortholog ANMT-1 competes with the methyltransferase LCMT-1 for methyl groups from S-adenosyl methionine. Thereby, it regulates the catalytic capacities of LCMT-1, targeting NPRL-2, a regulator of autophagy. During aging, high neuronal ANMT-1 activity induce autophagy via NPRL-2. In younger animals, ANMT-1 activity disturbs neuronal homeostasis and dopamine signaling, causing abnormal behavior | Caenorhabditis elegans |