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Literature summary for 2.1.1.1 extracted from
- Nicotinamide N-methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells (2019), Oncol. Rep., 42, 1805-1814 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P40261 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| UM-SCC-12 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NNMT | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression is upregulated in the cutaneous squamous cell carcinoma SCC-12 cell line | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | shRNA-mediated downregulation of NNMT expression levels inhibits the proliferation and density?-ependent growth of SCC-12 cells. The migration and invasion ofSCC cells are markedly decreased in NNMT-nockdown cells. High NNMT expression levels are accompanied by high expression levels of EMT-ssociated genes, and NNMT knockdown effectively suppresses the expression of matrix metalloproteinase 9, osteopontin, versican core protein and zinc finger protein SNAI2 in SCC-12 cells | Homo sapiens |
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Release 2023.1 (January 2023)
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