Literature summary for 2.1.1.1 extracted from

Li, Q.; He, M.D.; Mao, L.; Wang, X.; Jiang, Y.L.; Li, M.; Lu, Y.H.; Yu, Z.P.; Zhou, Z.
Nicotinamide N-methyltransferase suppression participates in nickel-induced histone H3 lysine9 dimethylation in BEAS-2B cells (2017), Cell. Physiol. Biochem., 41, 2016-2026 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Nickel	exposure of BEAS-2B cells to induces NNMT repression at both the protein and mRNA levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P40261	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BEAS-2B cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	exposure of BEAS-2B cells to induces NNMT repression at both the protein and mRNA levels	down
Homo sapiens	exposure to nickel induces NNMT repression at both the protein and mRNA levels	down

General Information

General Information	Comment	Organism
physiological function	exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation (H3K9me2), suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Over-expression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio	Homo sapiens
physiological function	exposure of BEAS-2B cells to nickel increases histone H3K9 dimethylation, suppresses the expressions of H3K9me2-associated genes MAP2K3 and DKK1, and induces NNMT repression at both the protein and mRNA levels. Overexpression of NNMT inhibits nickel-induced H3K9me2 and alters the cellular SAM/SAH ratio	Homo sapiens

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Release 2023.1 (January 2023)